| Methods |
Randomised
double‐blind
placebo control
Parallel trial.
Computer‐generated random number list.
2 week treatment |
| Participants |
Included:
Inpatients
none treatment‐resistant
Hight‐handed
DSM‐IV criteria for major depression.
Clinical interview and review of past data.
>15 in (HDRS)
Excluded:
history of major brain trauma, seizure disorder, substance abuse.
Number randomised: 70
Mean age: 58.2 (17.2)
Men: 17
Women: 53
3 withdrawals
Patients were maintained with their previous medication regimens |
| Interventions |
rTMS (1Hz at 110% motor threshold, 1200 total pulses, 2 trains per session, 60'' train duration) over the right prefrontal cortex + current medication vs Sham TMS + current medication Coil: circular 9 cm. |
| Outcomes |
Hamilton Depression Rating Scale‐17 item
Montgomery‐Asberg Depression Rating Scale
Global Impression Scale |
| Notes |
The patients were assessed by a single rater (senior psychiatry, who was involved in the diagnostic evaluation but was blind to the nature of treatment. |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Allocation concealment (selection bias) |
Unclear risk |
B ‐ Unclear |
