Comparison 2. Multiple versus single NSAID dose regimen.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Change in creatinine clearance (mL/min) on Day 1	6		Mean Difference (IV, Random, 95% CI)	Subtotals only
1.1 Multiple NSAID doses versus placebo	3	66	Mean Difference (IV, Random, 95% CI)	‐24.63 [‐42.29, ‐6.98]
1.2 Single NSAID dose versus placebo	3	75	Mean Difference (IV, Random, 95% CI)	‐10.40 [‐25.65, 4.86]
2 Change in creatinine clearance (mL/min) on Day 2	4		Mean Difference (IV, Random, 95% CI)	Subtotals only
2.1 Multiple NSAID doses versus placebo	2	44	Mean Difference (IV, Random, 95% CI)	‐7.59 [‐30.66, 15.47]
2.2 Single NSAID dose versus placebo	2	70	Mean Difference (IV, Random, 95% CI)	1.22 [‐33.27, 35.72]