| Methods |
Double‐blind, randomised, placebo controlled trial.
Randomisation method: not stated.
No patients withdrew from study.
No power calculation. |
| Participants |
26 (22 males, 4 females) patients undergoing infrarenal aortic surgery.
Exclusions: NSAIDs at least 7 days prior to surgery, history of renal disease, evidence for renal artery stenosis on preoperative aortography, drugs likely to alter renal function. |
| Interventions |
Rx: ibuprofen 400 mg IV before skin incision
Pl: Placebo aliquot IV before skin incision |
| Outcomes |
Pre‐operative and post‐operative creatinine clearance, fractional excretion of sodium, number of patients given diuretic or dopamine to treat post‐operative renal insufficiency. |
| Notes |
All patients were given post‐operative dopamine.
Frusemide 10 mg IV was given when urine output was less than 0.5 mL/kg/h |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Allocation concealment (selection bias) |
Unclear risk |
B ‐ Unclear |
