| Methods |
Randomisation method: not stated.
60 patients randomly allocated to diclofenac, etodolac or tramadol.
No details about blinding.
No loss of follow‐up.
No power calculation. |
| Participants |
Patients undergoing coronary artery bypass operation.
Exclusion: aged more than 70 years, left ventricular ejection fraction less than 30%, previous history of peptic ulcer disease or gastrointestinal bleeding, hepatic or renal insufficiency, known allergy to tramadol or NSAIDs, and preoperative analgesic treatment. Postoperative period exclusion criteria were delayed transfer to the general ward, serum creatinine more than 150 μmol/L, and altered mental status. |
| Interventions |
Rx1: diclofenac 50 mg every 8 hours orally on postoperative days 2 and 3.
Rx2: etodolac 300 mg every 8 hours orally on postoperative days 2 and 3 |
| Outcomes |
Pre‐operative and post‐operative serum creatinine. |
| Notes |
Tramadol group (weak opioid) not included in analysis. Postoperative day 1 serum creatinine data not included as study drugs were not given. Creatinine clearance measured on postoperative day 4. |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Allocation concealment (selection bias) |
Unclear risk |
B ‐ Unclear |
