| Methods |
Double‐blind, randomised, placebo controlled trial.
Randomisation method not stated.
One patient withdrew from study.
No details about intention to treat analysis or power calculation. |
| Participants |
22 males undergoing minor orthopaedic surgery.
Exclusions: patients with respiratory, cardiac, hepatic or renal insufficiency, a history of peptic ulcer disease or allergy to aspirin, diclofenac or other prostaglandin inhibiting compounds. |
| Interventions |
Rx: Diclofenac 100 mg suppository before surgery then 100 mg on Day 1
Pl: Placebo suppository before surgery and on Day 1 |
| Outcomes |
Pre‐operative and post‐operative creatinine clearance, urine output, sodium output, potassium output, fractional excretion of sodium, fractional excretion of potassium. |
| Notes |
Day 2 measures were not used as no diclofenac was administered on Day 2. |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Allocation concealment (selection bias) |
Unclear risk |
B ‐ Unclear |
