| Methods |
Double‐blind, randomised placebo controlled trial.
No patient withdrawal.
Sample size calculated.
Intention‐to‐treat analysis done. |
| Participants |
30 women (50 to 70 years) undergoing major gynaecological surgery.
Exclusions: renal or hepatic impairment, bleeding diathesis, hypersensitivity to NSAIDs, asthma, medications known to interfere with tenoxicam disposition. |
| Interventions |
Rx: Tenoxicam 20 mg IV given 2 hours before surgery.
Pl: Normal saline IV given 2 hours before surgery. |
| Outcomes |
Pre‐operative and post‐operative creatinine clearance, serum creatinine, fractional excretion of sodium and potassium. |
| Notes |
|
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Allocation concealment (selection bias) |
Low risk |
A ‐ Adequate |
