| Methods |
Double‐blind, randomised, placebo controlled trial.
Randomisation method: not stated.
Three patients withdrew from study.
No details about intention to treat analysis or power calculation. |
| Participants |
76 (26 males, 50 females) undergoing total hip (n = 62) or knee (n = 14) replacement.
Exclusions: hepatic, renal or cardiac failure, bleeding or coagulation disorders, peptic ulcer, asthma, hypersensitivity to aspirin or other NSAIDs, or who were on cytostatic treatment |
| Interventions |
Rx 1: 50 mg ketoprofen IV loading dose for 30 minutes, followed 50 mg ketoprofen infusion over following 11.5 hours.
Rx 2: 100 mg ketoprofen IV loading dose for 30 minutes, followed 100 mg ketoprofen infusion over following 11.5 hours.
Rx 3: 150 mg ketoprofen IV loading dose for 30 minutes, followed 150 mg ketoprofen infusion over following 11.5 hours.
Pl: Isotonic saline infusion for 30 minutes, followed by saline over following 11.5 hours (n = 19). |
| Outcomes |
Pre‐operative and Day 2 serum creatinine. |
| Notes |
Not pooled because serum creatinine was measured after drug had been eliminated (more than 5 half‐life). |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Allocation concealment (selection bias) |
Unclear risk |
B ‐ Unclear |
