| Methods |
Double‐blind, randomised, placebo controlled trial.
Randomisation method: not stated.
Twelve patients withdrew from study.
No intention to treat analysis but power calculation done |
| Participants |
210 women undergoing abdominal hysterectomy.
Exclusions: major organ dysfunction, history of allergic reactions to opioid analgesics or NSAIDs, bronchial asthma, gastrointestinal ulceration, bleeding disorders, or concurrent anticoagulant therapy. |
| Interventions |
Rx: Ketorolac 60 mg IV bolus before end of surgery then 30 mg over 30 minutes every 6 hours for 72 hours
Pl: 2 mL normal saline IV before end of surgery then 20 mL normal saline IV infusion over 30 minutes every 6 hours for 72 hours |
| Outcomes |
Pre‐operative and hospital discharge serum creatinine. |
| Notes |
Median serum creatinine levels given but time of hospital discharge was variable among women. |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Allocation concealment (selection bias) |
Unclear risk |
B ‐ Unclear |
