| Methods |
Double‐blind, randomised, placebo controlled trial.
Randomisation method: not stated.
No patients withdrew from study.
No power calculation. |
| Participants |
30 (24 males, 16 females) patients undergoing thoracotomy.
Exclusions: aged more than 75 years; clinically manifest cardiac, renal or hepatic failure; history of gastrointestinal bleeding or peptic ulceration, haemorrhagic diathesis and asthma or allergy to aspirin or diclofenac; confusion, estimated preoperative FEV1<1 L/s. |
| Interventions |
Rx: diclofenac 25 mg IV bolus on arrival into recovery room then 2 mg/kg IV infusion for 48 hours
Pl: saline infusion started with bolus dose of 25 mL in 15 minutes and continued with a constant rate of 2 mL/kg/d for 48 hours. |
| Outcomes |
Pre‐operative and post‐operative serum creatinine, proportion of patients with urine output less then 100 mL during Day 1. |
| Notes |
No pre‐operative urine output measure. |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Allocation concealment (selection bias) |
Unclear risk |
B ‐ Unclear |
