Summary of findings for the main comparison. Internal jugular versus subclavian insertion: long‐term catheterization for the prevention of venous thrombosis, stenosis and infection.
| Internal jugular versus subclavian insertion: long‐term catheterization for the prevention of venous thrombosis, stenosis and infection | ||||||
| Patient or population: cancer patients Settings: inpatient Intervention: Internal jugular versus subclavian insertion: long‐term catheterization | ||||||
| Outcomes | Illustrative comparative risks* (95% CI) | Relative effect (95% CI) | No of Participants (studies) | Quality of the evidence (GRADE) | Comments | |
| Assumed risk | Corresponding risk | |||||
| Control | versus subclavian insertion: long‐term catheterization | |||||
| Catheter‐related infectious complications ‐ Exit site infection | Study population | RR 7 (0.88 to 55.86) | 200 (1 study) | ⊕⊕⊝⊝ low1,2,3,4 | ||
| 10 per 1000 | 70 per 1000 (9 to 559) | |||||
| Moderate | ||||||
| 10 per 1000 | 70 per 1000 (9 to 559) | |||||
| Catheter‐related infectious complications ‐ Port‐related bacteraemia and/or pocket infections | Study population | RR 0.35 (0.04 to 3.32) | 240 (1 study) | ⊕⊕⊕⊝ moderate1,2 | ||
| 24 per 1000 | 9 per 1000 (1 to 81) | |||||
| Moderate | ||||||
| 24 per 1000 | 8 per 1000 (1 to 80) | |||||
| Catheter‐related thrombotic complications | Study population | RR 1.97 (0.87 to 4.48) | 240 (1 study) | ⊕⊕⊕⊝ moderate1,2 | ||
| 65 per 1000 | 128 per 1000 (57 to 291) | |||||
| Moderate | ||||||
| 65 per 1000 | 128 per 1000 (57 to 291) | |||||
| Immediate mechanical complications ‐ Total mechanical complications | Study population | RR 1 (0.21 to 4.84) | 468 (2 studies) | ⊕⊕⊝⊝ low1,2,3,4 | ||
| 13 per 1000 | 13 per 1000 (3 to 62) | |||||
| Moderate | ||||||
| 15 per 1000 | 15 per 1000 (3 to 73) | |||||
| Immediate mechanical complications ‐ Major mechanical complications | Study population | RR 0.33 (0.01 to 8.09) | 468 (2 studies) | ⊕⊕⊝⊝ low1,2,3,4 | ||
| 4 per 1000 | 1 per 1000 (0 to 34) | |||||
| Moderate | ||||||
| 5 per 1000 | 2 per 1000 (0 to 40) | |||||
| Late mechanical complications | Study population | RR 1.67 (0.41 to 6.79) | 468 (2 studies) | ⊕⊕⊝⊝ low1,2,3,4 | ||
| 13 per 1000 | 21 per 1000 (5 to 86) | |||||
| Moderate | ||||||
| 15 per 1000 | 25 per 1000 (6 to 102) | |||||
| *The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: Confidence interval; RR: Risk ratio; | ||||||
| GRADE Working Group grades of evidence High quality: Further research is very unlikely to change our confidence in the estimate of effect. Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate. Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate. Very low quality: We are very uncertain about the estimate. | ||||||
1 Blinding not well described. 2 Concealment not well described. 3 Incomplete outcome data addressed. 4 Selective reporting addressed.