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. 2012 Mar 14;2012(3):CD004084. doi: 10.1002/14651858.CD004084.pub3

Summary of findings 2. Femoral versus subclavian insertion: short‐term catheterization for the prevention of venous thrombosis, stenosis and infection.

Femoral versus subclavian insertion: short‐term catheterization for the prevention of venous thrombosis, stenosis and infection
Patient or population: critically ill patients
 Intervention: Femoral versus subclavian insertion: short‐term catheterization
Outcomes Illustrative comparative risks* (95% CI) Relative effect
 (95% CI) No of Participants
 (studies) Quality of the evidence
 (GRADE) Comments
Assumed risk Corresponding risk
Control Femoral versus subclavian insertion: short‐term catheterization
Catheter‐related infectious complications ‐ Catheter colonization Study population RR 6.43 
 (1.95 to 21.21) 270
 (1 study) ⊕⊕⊕⊕
 high  
22 per 1000 142 per 1000
 (43 to 468)
Moderate
22 per 1000 141 per 1000
 (43 to 467)
Catheter‐related infectious complications ‐ Catheter‐related bloodstream infection Study population RR 2.03 
 (0.19 to 22.12) 270
 (1 study) ⊕⊕⊕⊕
 high  
7 per 1000 15 per 1000
 (1 to 163)
Moderate
7 per 1000 14 per 1000
 (1 to 155)
Catheter‐related thrombotic complications Study population RR 11.53 
 (2.8 to 47.52) 223
 (1 study) ⊕⊕⊕⊕
 high  
19 per 1000 216 per 1000
 (52 to 888)
Moderate
19 per 1000 219 per 1000
 (53 to 903)
Immediate mechanical complications ‐ Total mechanical complications Study population RR 0.92 
 (0.56 to 1.51) 289
 (1 study) ⊕⊕⊕⊕
 high  
188 per 1000 172 per 1000
 (105 to 283)
Moderate
188 per 1000 173 per 1000
 (105 to 284)
Immediate mechanical complications ‐ Major mechanical complications Study population RR 0.5 
 (0.09 to 2.67) 289
 (1 study) ⊕⊕⊕⊕
 high  
28 per 1000 14 per 1000
 (3 to 74)
Moderate
28 per 1000 14 per 1000
 (3 to 75)
*The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI).
 CI: Confidence interval; RR: Risk ratio;
GRADE Working Group grades of evidence
 High quality: Further research is very unlikely to change our confidence in the estimate of effect.
 Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate.
 Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate.
 Very low quality: We are very uncertain about the estimate.