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#1 exp Catheterization, Central Venous/ or (central adj3 venous*).ti,ab. or ((central venous or CVA or jugular or subclav* or femoral or catheter* or cannula) adj5 (access* or rout* or site* or area)).mp. or CVA*.ti,ab. or (CVA adj5 (neck or chest or femor*)).mp. or ((access or CVA*) adj3 devic*).mp #2 exp catheter‐related infections/ or Venous Thrombosis/ or (thromb* or fibrin* or occlu* or block* or stenos* or infect*).ti,ab. or (blood adj5 (clot* or vessel* narrow*)).mp #3 ((randomized controlled trial or controlled clinical trial).pt. or randomized.ab. or placebo.ab. or clinical trials as topic.sh. or randomly.ab. or trial.ti.) not (animals not (humans and animals)).sh. #4 1 and 2 and 3