Biffi 2009.

Methods	Allocation: randomized, randomization was intraoperatively carried out by the data manager of the trial using a computer‐assisted procedure and communicated to the operators. Blinding : No description. Duration (mean (range),d): 596 (0‐1087).
Participants	Diagnosis: Hospitalized adults (aged 18‐75) with an Eastern Cooperative Oncology Group performance status of zero to two, bearing solid tumours and candidate for iv chemotherapy. Age (mean (SD), y ): 52.0 (11.9). Sex: F 313, M 90. Setting: The European Institute of Oncology in Milan, Italy.
Interventions	1. Percutaneous landmark access to the internal jugular site (n=134). 2. Ultrasound (US) guided access to the subclavian site (n=136). 3. Surgical cut‐down access through cephalic vein site (n=133).
Outcomes	Catheter‐related infectious complications: Port‐related bacteraemia and/or pocket infection. Catheter‐related thrombotic complications. Mechanical complications. Leaving study early.
Notes	Only interventions 1, 2 included in the review.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Randomization was intraoperatively carried out by the data manager of the trial using a computer‐assisted procedure and communicated to the operators.
Allocation concealment (selection bias)	Unclear risk	No description.
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	No description.
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	No description.
Incomplete outcome data (attrition bias) All outcomes	Low risk	Description of reasons why terminated.
Selective reporting (reporting bias)	Low risk	Reported all data.
Other bias	Unclear risk	No description.