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. 2018 Oct 29;2018(10):CD012661. doi: 10.1002/14651858.CD012661.pub2
Study ID Rate (diabetes cases/1000 person‐years (95% CI))
Follow‐up (years) NGT cohort 'Prediabetes' cohort IFG6.1 cohort IFG5.6 cohort IGT cohort IFG/IGT cohort Elevated HbA1c cohort Elevated HbA1c/IFG cohort
Anjana 2015 9.1 22.2 (19.4–25.4) 78.9 (68.0–90.9) 61.0 (42.1–85.0) 67.8 (54.6–83.0) 133.6 (103.1– 169.3)
Bae 2011 4 Per 100 person‐years:
HbA1c5.7: 5.6
HbA1c6.0: 14.0
Bonora 2011 15 10 years: 4.3 (2.7–5.9) 10 years: 37.0 (20.2–53.8) 10 years: 17.0 (5.3–28.7) 10 years: 49.2 (17.9–80.5) HbA1c6.0: 25.8
De Abreu 2015 10 18.1 (10.7–28.2)
Derakhshan 2016 11.7 30.3 6.5 years:
 69.4 (56.0–86.1) 6.5 years:
 39.5 (34.4–45.4) 6.5 years:
 41.6 (36.1–47.9)
Dowse 1991 6.2 10.5 40.4
Forouhi 2007 10 2.4 (1.2–4.8)
4 years: 2.64 (1.23–4.05)
17.5 (12.5–24.5) 10.6 (8.1–13.9)
(IFG5.6: FPG 5.6–6.9)
4 years: 22.5 (20.4–24.6)
Han 2017 12 12.3 IFG or IGT: 58.0 i‐IFG5.6: 51.3 i‐IGT: 53.1 114.4 10 years:
HbA1c5.7: 43.2
Heianza 2012 5 2.3 104 34.6 HbA1c5.7: 51.0
HbA1c6.0: 129.2
HbA1c5.7 and IFG5.6: 30.6
HbA1c6.0 and IFG5.6: 34.4
Janghorbani 2015 6.8 3.1 (1.5–4.7)
 2.3 years: 4.6 (1.28–11.7) 16.3 (10.3–24.4)
 2.3 years: i‐IFG5.6: 50.7 (20.7–102.0) 25.9 (17.0–37.7)
2.3 years: i‐IGT: 99.7 (77.1–126.0)
57.9 (46.1–71.7)
Jiamjarasrangsi 2008a 2.6 31.5 (11.4–86.8)
Latifi 2016 5 21.9 34.5
Li 2003 5 18.8 93.7 60.7 117
Ligthart 2016 14.7 43.0 (39.2–47.2)
Liu 2008 5 9 22.5
Magliano 2008 5 0.2 (0.2–0.3)
 (incidence percent per years) i‐IFG6.1: 2.6 (1.8–3.4)
(incidence percent per years)
i‐IGT: 3.5 (2.9–4.2)
(incidence percent per years)
Meigs 2003 5, 10 Per 100 person‐years (annualised rate): FPG ≥ 7.0:
 0.64 (0.32–1.13)
 2‐h PG ≥ 11.1:
2.77 (2.01–3.71)
Per 100 person‐years (annualised rate):
IFG or IGT
FPG ≥ 7.0:
 0.98 (0.65–1.41)
 2‐h PG ≥ 11.1:
4.61 (3.77–5.56)
Mohan 2008 8 17.5 64.8
Nakagami 2016 5 1
Nakanishi 2004 7 1.5 3.3
Park 2006 4.1 5.7 31.3
Rajala 2000 4.6 41 (28–57)
Rasmussen 2008 3.5
 (i‐IFG5.6: 2.5 , IGT: 2.1 ) i‐IFG5.6:
 11.8 (9.9–13.8)
 per 100 person‐years 17.0 (14.9–19.1)
 per 100 person‐years
(i‐IGT: 11.8 (9.7–13.9)
27 (22.5–31.7)
 per 100 person‐years
Rathmann 2009 7 i‐IFG6.1:
 24.2 (12.5–42.3) i‐IGT:
 42.0 (29.0–58.7) 77.9 (48.8–117.9)
Rijkelijkhuizen 2007 6.4 7 66.5 (49.9–83.0) 32.7 (26.3–39.1) i‐IGT: 57.9 112.2
Sadeghi 2015 7 Total: 14.1 (12.5–15.9)
Men: 12.8 (10.7–15.3)
 Women: 15.5 (13.1–18.3)
Total: 48.4 (35.0–66.7)
 Men: 46.4 (28.9–74.7)
 Women: 50.1 (32.3–77.7) Total: 40.3 (30.2–53.8)
 Men: 41.4 (25.7–66.6)
 Women: 39.6 (27.5–57.0) Total: 137.6 (103.7–182.5)
 Men: 129.9 (83.0–203.7)
 Women: 143.1 (99.4–205.9)
Söderberg 2004 11 87–92:
 Men: 54.1 (48.0–60.1)
 Women: 35.1 (30.3–40.0)
92–98:
 Men: 60.5 (54.1–67.0)
 Women: 74–7 (67.8–81.8)
87–92:
 Men: 60.7 (54.3–67.1)
 Women: 47.9 (42.2–53.6)
92–98:
 Men: 119.6 (110.6–128.6)
 Women: 81.0 (73.6–88.4)
Soriguer 2008 6 7.2 (4.2–12.4) 38.1 (25.3–57.3) 31.1 (18.4–52.5) 66.0 (39.1–111.5)
Valdes 2008 6.3 3.8 (2.1–6.8)
for i‐IGT and IFG/IGT:
5.0 (2.8–8)
58.0 (37–90.9) 19.5 (11.5–32.9) 37.9 (24.7–58.1)
i‐IGT: 21 (10.9–40.4)
95.2 (54.1–167.7)
Vijayakumar 2017 Adults: 4.6
 Children: 5.2 Boys: 22
 Men: 70
 Girls: 55
 Women: 101 Boys: 38
 Men: 94
 Girls: 60
 Women: 118 Boys: 52
 Men: 100
 Girls: 100
 Women: 118
Wang 2011 7.8 21.1 Total: 66.2
Men: 57.7
Women: 73.4
Total: 95.8
Men: 98.1
Women: 94.8
Total: 109
Men: 109
Women: 109
CI: confidence interval; FPG: fasting plasma glucose; HbA1c: glycosylated haemoglobin A1c; HbA1c5.7/6.0: HbA1c threshold 5.7% or 6.0% (usually reflecting 5.7% to 6.4% and 6.0% to 6.4%, respectively); HbA1c/IFG: both HbA1c and IFG; i‐: isolated; IFG5.6/6.1: impaired fasting glucose (threshold 5.6 mmol/L or 6.1 mmol/L); IGT: impaired glucose tolerance; IFG/IGT: both IFG and IGT;NGT: normal glucose tolerance; T2DM: type 2 diabetes mellitus