Study ID | Rate (diabetes cases/1000 person‐years (95% CI)) | ||||||||
Follow‐up (years) | NGT cohort | 'Prediabetes' cohort | IFG6.1 cohort | IFG5.6 cohort | IGT cohort | IFG/IGT cohort | Elevated HbA1c cohort | Elevated HbA1c/IFG cohort | |
Anjana 2015 | 9.1 | 22.2 (19.4–25.4) | 78.9 (68.0–90.9) | — | 61.0 (42.1–85.0) | 67.8 (54.6–83.0) | 133.6 (103.1– 169.3) | — | — |
Bae 2011 | 4 | — | — | — | — | — | — | Per 100 person‐years: HbA1c5.7: 5.6 HbA1c6.0: 14.0 |
— |
Bonora 2011 | 15 | 10 years: 4.3 (2.7–5.9) | — | 10 years: 37.0 (20.2–53.8) | — | 10 years: 17.0 (5.3–28.7) | 10 years: 49.2 (17.9–80.5) | HbA1c6.0: 25.8 | — |
De Abreu 2015 | 10 | — | — | — | 18.1 (10.7–28.2) | — | — | — | — |
Derakhshan 2016 | 11.7 | — | 30.3 | 6.5 years: 69.4 (56.0–86.1) | 6.5 years: 39.5 (34.4–45.4) | 6.5 years: 41.6 (36.1–47.9) | — | — | — |
Dowse 1991 | 6.2 | 10.5 | — | — | — | 40.4 | — | — | — |
Forouhi 2007 | 10 | 2.4 (1.2–4.8) 4 years: 2.64 (1.23–4.05) |
— | 17.5 (12.5–24.5) | 10.6 (8.1–13.9) (IFG5.6: FPG 5.6–6.9) |
4 years: 22.5 (20.4–24.6) | — | — | — |
Han 2017 | 12 | 12.3 | IFG or IGT: 58.0 | — | i‐IFG5.6: 51.3 | i‐IGT: 53.1 | 114.4 | 10 years: HbA1c5.7: 43.2 |
— |
Heianza 2012 | 5 | 2.3 | — | 104 | 34.6 | — | — | HbA1c5.7: 51.0 HbA1c6.0: 129.2 |
HbA1c5.7 and IFG5.6: 30.6 HbA1c6.0 and IFG5.6: 34.4 |
Janghorbani 2015 | 6.8 | 3.1 (1.5–4.7) 2.3 years: 4.6 (1.28–11.7) | — | — | 16.3 (10.3–24.4) 2.3 years: i‐IFG5.6: 50.7 (20.7–102.0) | 25.9 (17.0–37.7) 2.3 years: i‐IGT: 99.7 (77.1–126.0) |
57.9 (46.1–71.7) | — | — |
Jiamjarasrangsi 2008a | 2.6 | — | — | — | 31.5 (11.4–86.8) | — | — | — | — |
Latifi 2016 | 5 | 21.9 | — | — | 34.5 | — | — | — | — |
Li 2003 | 5 | 18.8 | — | 93.7 | — | 60.7 | 117 | — | — |
Ligthart 2016 | 14.7 | — | — | 43.0 (39.2–47.2) | — | — | — | — | — |
Liu 2008 | 5 | 9 | — | — | 22.5 | — | — | — | — |
Magliano 2008 | 5 | 0.2 (0.2–0.3) (incidence percent per years) | — | i‐IFG6.1: 2.6 (1.8–3.4) (incidence percent per years) |
— | i‐IGT: 3.5 (2.9–4.2) (incidence percent per years) |
— | — | — |
Meigs 2003 | 5, 10 | Per 100 person‐years (annualised rate): FPG ≥ 7.0:
0.64 (0.32–1.13)
2‐h PG ≥ 11.1: 2.77 (2.01–3.71) |
— | — | — | — | Per 100 person‐years (annualised rate): IFG or IGT FPG ≥ 7.0: 0.98 (0.65–1.41) 2‐h PG ≥ 11.1: 4.61 (3.77–5.56) |
— | — |
Mohan 2008 | 8 | 17.5 | — | — | — | 64.8 | — | — | — |
Nakagami 2016 | 5 | — | — | 1 | — | — | — | — | — |
Nakanishi 2004 | 7 | 1.5 | — | 3.3 | — | — | — | — | — |
Park 2006 | 4.1 | 5.7 | — | — | 31.3 | — | — | — | — |
Rajala 2000 | 4.6 | — | — | — | — | 41 (28–57) | — | — | — |
Rasmussen 2008 | 3.5 (i‐IFG5.6: 2.5 , IGT: 2.1 ) | — | — | — | i‐IFG5.6: 11.8 (9.9–13.8) per 100 person‐years | 17.0 (14.9–19.1)
per 100 person‐years (i‐IGT: 11.8 (9.7–13.9) |
27 (22.5–31.7) per 100 person‐years | — | — |
Rathmann 2009 | 7 | — | — | i‐IFG6.1: 24.2 (12.5–42.3) | — | i‐IGT: 42.0 (29.0–58.7) | 77.9 (48.8–117.9) | — | — |
Rijkelijkhuizen 2007 | 6.4 | 7 | — | 66.5 (49.9–83.0) | 32.7 (26.3–39.1) | i‐IGT: 57.9 | 112.2 | — | — |
Sadeghi 2015 | 7 | Total: 14.1 (12.5–15.9) Men: 12.8 (10.7–15.3) Women: 15.5 (13.1–18.3) |
— | — | Total: 48.4 (35.0–66.7) Men: 46.4 (28.9–74.7) Women: 50.1 (32.3–77.7) | Total: 40.3 (30.2–53.8) Men: 41.4 (25.7–66.6) Women: 39.6 (27.5–57.0) | Total: 137.6 (103.7–182.5) Men: 129.9 (83.0–203.7) Women: 143.1 (99.4–205.9) | — | — |
Söderberg 2004 | 11 | — | — | 87–92:
Men: 54.1 (48.0–60.1)
Women: 35.1 (30.3–40.0) 92–98: Men: 60.5 (54.1–67.0) Women: 74–7 (67.8–81.8) |
— | 87–92:
Men: 60.7 (54.3–67.1)
Women: 47.9 (42.2–53.6) 92–98: Men: 119.6 (110.6–128.6) Women: 81.0 (73.6–88.4) |
— | — | — |
Soriguer 2008 | 6 | 7.2 (4.2–12.4) | — | — | 38.1 (25.3–57.3) | 31.1 (18.4–52.5) | 66.0 (39.1–111.5) | — | — |
Valdes 2008 | 6.3 | 3.8 (2.1–6.8) for i‐IGT and IFG/IGT: 5.0 (2.8–8) |
— | 58.0 (37–90.9) | 19.5 (11.5–32.9) | 37.9 (24.7–58.1) i‐IGT: 21 (10.9–40.4) |
95.2 (54.1–167.7) | — | — |
Vijayakumar 2017 | Adults: 4.6 Children: 5.2 | — | — | — | Boys: 22 Men: 70 Girls: 55 Women: 101 | Boys: 38 Men: 94 Girls: 60 Women: 118 | — | Boys: 52 Men: 100 Girls: 100 Women: 118 | — |
Wang 2011 | 7.8 | 21.1 | — | — | Total: 66.2 Men: 57.7 Women: 73.4 |
Total: 95.8 Men: 98.1 Women: 94.8 |
Total: 109 Men: 109 Women: 109 |
— | — |
CI: confidence interval; FPG: fasting plasma glucose; HbA1c: glycosylated haemoglobin A1c; HbA1c5.7/6.0: HbA1c threshold 5.7% or 6.0% (usually reflecting 5.7% to 6.4% and 6.0% to 6.4%, respectively); HbA1c/IFG: both HbA1c and IFG; i‐: isolated; IFG5.6/6.1: impaired fasting glucose (threshold 5.6 mmol/L or 6.1 mmol/L); IGT: impaired glucose tolerance; IFG/IGT: both IFG and IGT;NGT: normal glucose tolerance; T2DM: type 2 diabetes mellitus |