| Name of study |
Data from an Epidemiological Study on the Insulin Resistance Syndrome (DESIR) cohort |
| Inclusion criteria |
Men and women aged 30–64 years recruited from volunteers who were offered periodic health examinations free of charge by the French Social Security at 10 health centres in western France |
| Exclusion criteria |
Diabetes at baseline, individuals with unknown diabetes status at the 9‐year examination |
| Notes |
No baseline data for cohort with intermediate hyperglycaemia |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Study participation: description of source population or population of interest |
Low risk |
Participants of the Data from an Epidemiological Study on the Insulin Resistance Syndrome (DESIR) cohort who had IFG at baseline |
| Study participation: description of glycaemic status at baseline |
Low risk |
Yes |
| Study participation: adequate description of sampling frame & recruitment |
Unclear risk |
Key characteristics unclear |
| Study participation: adequate description of period & recruitment place |
Unclear risk |
Time frame unclear |
| Study participation: adequate description of inclusion & exclusion criteria |
Low risk |
Inclusion and exclusion criteria described |
| Study attrition: description of attempts to collect information on participants who dropped out |
High risk |
Not reported |
| Study attrition: reasons for loss to follow‐up provided |
Unclear risk |
Scarce data |
| Study attrition: adequate description of participants lost to follow‐up |
Unclear risk |
Scarce data |
| Study attrition: no important differences between participants who completed the study and those who did not |
Unclear risk |
Not reported |
| Glycaemic status measurement: provision of clear definition or description of glycaemic status |
Low risk |
IFG |
| Glycaemic status measurement: valid and reliable method of glycaemic status measurement |
Low risk |
Yes |
| Glycaemic status measurement: continuous variables reported or appropriate cut points used |
Low risk |
IFG: FPG 5.6–6.9 |
| Glycaemic status measurement: same method and setting of measurement of the glycaemic status for all study participants |
Low risk |
Yes |
| Outcome measurement: clear definition of the outcome provided |
Low risk |
FPG ≥ 7.0; treatment for diabetes (at 1 of the 3‐yearly examinations) |
| Outcome measurement: method of outcome measurement used valid & reliable |
Low risk |
Yes |
| Outcome measurement: same method & setting of outcome measurement for all study participants |
Low risk |
Yes |
| Study confounding: important confounders measured |
Low risk |
Some confounders measured |
| Study confounding: clear definitions of important confounders provided |
Low risk |
Yes |
| Study confounding: measurement of confounders valid & reliable |
Low risk |
Yes |
| Study confounding: same method & setting for measurements of confounders for all study participants |
Unclear risk |
Yes |
| Study confounding: appropriate methods used if missing confounder data imputed |
Unclear risk |
Not reported |
| Study confounding: important potential confounders accounted for in study design |
Low risk |
Yes (see below) |
| Study confounding: important potential confounders accounted for in the analysis |
Low risk |
Yes (see below) |
| Statistical analysis & reporting: sufficient presentation of data to assess adequacy of the analytic strategy |
Low risk |
Cumulative incidence (odds ratios for 9‐year incident diabetes per 1 SD change in waist circumference and weight in IFG) |
| Statistical analysis & reporting: the statistical model is adequate for the design of the study |
Low risk |
Logistic models (for increases in waist circumference and weight) |
