| Name of study |
None |
| Inclusion criteria |
Men and non‐pregnant women, aged 20–64 years, were recruited from the city of Durango, northern Mexico; with NGT or IGT |
| Exclusion criteria |
Participants who failed to attend 2 or more visits |
| Notes |
Baseline data for IGT cohort at baseline progressing to T2DM (N = 20); all individuals were counselled on the importance of diet and physical exercise (standard care for the whole cohort) |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Study participation: description of source population or population of interest |
Low risk |
Cohort study in healthy Mexicans to determine predictors for the development of metabolic disorders |
| Study participation: description of glycaemic status at baseline |
Low risk |
Yes |
| Study participation: adequate description of sampling frame & recruitment |
Unclear risk |
Time frame unclear |
| Study participation: adequate description of period & recruitment place |
Unclear risk |
Period of recruitment unclear |
| Study participation: adequate description of inclusion & exclusion criteria |
Low risk |
Inclusion and exclusion criteria described |
| Study attrition: description of attempts to collect information on participants who dropped out |
Unclear risk |
Not reported |
| Study attrition: reasons for loss to follow‐up provided |
Unclear risk |
Not reported |
| Study attrition: adequate description of participants lost to follow‐up |
Unclear risk |
Not reported |
| Study attrition: no important differences between participants who completed the study and those who did not |
Unclear risk |
Not reported |
| Glycaemic status measurement: provision of clear definition or description of glycaemic status |
Low risk |
IGT |
| Glycaemic status measurement: valid and reliable method of glycaemic status measurement |
Low risk |
Yes |
| Glycaemic status measurement: continuous variables reported or appropriate cut points used |
Low risk |
IGT: 2‐h PG ≥ 7.8 to < 11.1 |
| Glycaemic status measurement: same method and setting of measurement of the glycaemic status for all study participants |
Low risk |
Yes |
| Outcome measurement: clear definition of the outcome provided |
Low risk |
2‐h PG: ≥ 11.1 |
| Outcome measurement: method of outcome measurement used valid & reliable |
Low risk |
Yes |
| Outcome measurement: same method & setting of outcome measurement for all study participants |
Low risk |
Yes |
| Study confounding: important confounders measured |
Unclear risk |
Some covariates measured (for association between beta‐cell function and IGT/T2DM) (see Appendix 16 and Appendix 17) |
| Study confounding: clear definitions of important confounders provided |
Unclear risk |
Not reported |
| Study confounding: measurement of confounders valid & reliable |
Unclear risk |
Not reported |
| Study confounding: same method & setting for measurements of confounders for all study participants |
Low risk |
Yes |
| Study confounding: appropriate methods used if missing confounder data imputed |
Unclear risk |
Not reported |
| Study confounding: important potential confounders accounted for in study design |
Low risk |
For beta‐cell function and IGT/T2DM |
| Study confounding: important potential confounders accounted for in the analysis |
Unclear risk |
Some confounders measured |
| Statistical analysis & reporting: sufficient presentation of data to assess adequacy of the analytic strategy |
Low risk |
Cumulative incidence, incidence rate |
| Statistical analysis & reporting: the statistical model is adequate for the design of the study |
Low risk |
Multivariate logistic regression on relative risk of IGT or T2DM associated with beta‐cell function |
