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. 2018 Dec 14;2018(12):CD011710. doi: 10.1002/14651858.CD011710.pub2

Knaevelsrud 2015.

Study characteristics
Methods Randomised controlled trial
Participants Sample size: 159
Diagnosis: DSM‐IV PTSD
Method of recruitment: advertisements and presentations at department of defence sites
Method of diagnosis: PDS used to identify if participants reported the minimum number of symptoms required by DSM‐IV for each of the symptom clusters (at least 1 intrusion, 3 avoidance, and 2 hyperarousal symptoms). Minimum score of 11 on the PDS required.
Trauma type: war related
Age (mean): interapy: 29.11 (SD 8.20) years; wait list: 27.15 (SD 6.48) years
Sex: interapy: 60 women (79%); wait list: 55 women (69%)
Location: Iraq
Comorbidities: unclear
Adjunctive therapy: excluded
Adjunctive medication: unclear
Unemployment: interapy: 26 (33%); wait list: 29 (36%)
University education: interapy: 56 (71%); wait list: 38 (48%)
Exclusion criteria: currently receiving treatment elsewhere; substance abuse or dependence; high risk of suicide; psychotic symptoms; low symptom severity
Baseline PDS scores (mean): interapy: 30.87 (SD 8.13); wait list: 31.81 (SD 7.13)
Interventions Internet programme based on trauma‐focused CBT versus wait list
Experimental arm
Interapy
Duration: 5 weeks
Treatment protocol
  • 2 weekly structured writing activities assigned each week over period of 5 weeks.

  • 3 treatment phases: self‐confrontation with the traumatic event, cognitive restructuring, and social sharing.


Type of contact: short homework reminder by e‐mail, if no response contacted by phone; exact method of communication unclear.
Automated contact: unknown, not reported
Type of therapist: native speaking psychotherapists
Treatment fidelity: weekly supervision sessions, either face‐to‐face or via Skype
Comparator arm
Duration: 6 weeks
Treatment protocol: participants were on a wait list for 6 weeks and then received the intervention.
Therapist contact: none
Outcomes PDS; HSCL‐25; EUROHIS‐QUOL
Notes Funding source: unclear
Declarations of interest among the primary researchers: unclear
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk Quote: "Randomisation was based on a computer‐generated randomisation list."
Allocation concealment (selection bias) Unclear risk Not reported
Blinding of participants and personnel (performance bias)
All outcomes High risk Quote: "researchers and psychotherapists were not masked to the intervention."
Blinding of outcome assessment (detection bias)
All outcomes Low risk Comment: self‐reported measures
Incomplete outcome data (attrition bias)
All outcomes High risk ITT analysis BUT missing data > 30%
Selective reporting (reporting bias) Low risk Study protocol available (Registered Trial (p.2) – Australian New Zealand Clinical Trial Registry) and the published reports included all expected outcomes, including those that were prespecified.
Other bias Low risk Study appeared free from other sources of bias.