de Groot 1997.

Methods	Randomised. double‐blind. placebo‐controlled trial. Single‐centre. Criteria for FD: equivalent symptom to Rome with both type of FD
Participants	N = 121 Female: 54% Mean age: 40.9 years for the prokinetic group and 43.9 years for the placebo group Country : the Netherlands
Interventions	Intervention: cisapride 10 mg three times a day Comparator: placebo No rescue medication Duration of treatment: 4 weeks
Outcomes	Physician's assessment of overall result as on 4‐point scales (excellent, good, moderate, poor), data reported as excellent or good
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Quote: "Randomized"
Allocation concealment (selection bias)	Unclear risk	No information
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Double‐blinded
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Assessed by doctor but we do not know if he was blinded
Incomplete outcome data (attrition bias) All outcomes	Low risk	7% not included in the analyses
Selective reporting (reporting bias)	Unclear risk	Combined excellent and good global response
Other bias	Low risk	No other risk found