Kellow 1995.

Methods	Randomised. double‐blind, placebo‐controlled trial. Single‐centre. Criteria for FD: equivalent symptom with mixed ulcer‐ like and dysmotility‐like
Participants	N = 61 Female: 70% Mean age: 50 ±18 years for prokinetic group and 46 ± 15 years for placebo group Country : Australia
Interventions	Intervention: cisapride 10 mg orally three times a day Comparator: placebo Rescue medication: antacid Duration of treatment: 4 weeks
Outcomes	Total score of symptoms based on scale 0 to 3 assessed by doctor Global assessment: marked improvement‐complete or near complete resolution of symptoms: moderate improvement‐partial remission of symptoms; minimal improvement‐slight improvement of symptoms: unchanged‐no change in symptoms; deteriorated‐symptoms worsened as compared to before treatment assessed by participants
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Quote: "Randomized"
Allocation concealment (selection bias)	Unclear risk	No information
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Double blinded
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Assessed by both investigators and participants who were blinded
Incomplete outcome data (attrition bias) All outcomes	Low risk	8% participants withdrawn (6.5% from prokinetic versus 10% from placebo), balanced between two groups
Selective reporting (reporting bias)	Low risk	Reported all pre‐defined outcomes
Other bias	Low risk	No other risk found