Yeoh 1997.

Methods	Randomised, double‐blind,placebo‐controlled trial. Single‐centre, Criteria for FD: equivalent symptom and included both types of FD
Participants	N = 104 Female: 53% Mean age:43.5+/‐2.2 years for the gastritis group and 35.6+/‐1.5 years for the non‐gastritis group Country: Singapore
Interventions	Intervention: cisapride 10 mg orally three times a day Comparator: placebo Rescue medication: antacid (open‐labelled) Duration of treatment: 4 weeks
Outcomes	Symptoms of epigastric pain, bloating, nausea, belching, early satiety and heartburn were graded on a 4‐point scale were assessed by participants A global response by physicians‐(i) poor, no change or deterioration of symptoms; (ii) fair, clear but limited improvement; (iii) good, considerable overall improvement; and (iv) excellent, complete or almost complete disappearance of symptoms
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Quote: "Randomly allocated"
Allocation concealment (selection bias)	Unclear risk	No information
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Double‐blinded
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Scores were assessed by participants, global response was assessed by physicians. It is not clear if outcome assessors were blinded
Incomplete outcome data (attrition bias) All outcomes	High risk	27% (28/104) participants did not complete the study
Selective reporting (reporting bias)	Low risk	Reproted all pre‐defined outcomes
Other bias	Low risk	No other risk of bias found