Comparison 1. Ibuprofen vs placebo in children.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1.1 Pain‐free	2	125	Risk Ratio (M‐H, Random, 95% CI)	1.87 [1.15, 3.04]
1.2 Adverse events (any)	1	80	Risk Difference (M‐H, Random, 95% CI)	0.00 [‐0.13, 0.13]
1.3 Headache relief	2	125	Risk Ratio (M‐H, Random, 95% CI)	1.49 [1.11, 2.00]
1.4 Rescue medication	2	164	Risk Ratio (M‐H, Random, 95% CI)	0.19 [0.02, 1.56]
1.5 Headache recurrence	1	38	Risk Ratio (M‐H, Fixed, 95% CI)	0.25 [0.01, 5.68]