1. exp Headache Disorders/ 2. vascular headaches/ 3. headache/ 4. (migraine$ or headache$ or head‐ache$ or cephalgia or cephalalgia).ti,ab. 5. or/1‐4 6. exp Drug Therapy/ 7. (ad or ae or dt or to).fs. 8. exp Treatment Outcome/ 9. exp Analgesics/ 10. "nonsteroidal anti‐inflammatory agent?".mp. 11. "non‐steroidal anti‐inflammatory agent?".mp. 12. NSAID?.mp. 13. ibuprofen.mp. 14. fenoprofen.mp. 15. flurbiprofen.mp. 16. ketoprofen.mp. 17. ketorolac.mp. 18. diclofenac.mp. 19. etodolac.mp. 20. sulindac.mp. 21. naproxen.mp. 22. tolmetin.mp. 23. oxaprozin.mp. 24. tenoxicam.mp. 25. tiaprofenic acid.mp. 26. mefenamic acid.mp. 27. ((acetylsalicylic adj1 acid) or aspirin).mp. 28. piroxicam.mp. 29. celecoxib.mp. 30. meloxicam.mp. 31. indomethacin.mp. 32. floctafenin$.mp. 33. nabumeton$.mp. 34. acetaminophen.mp. 35. paracetamol.mp. 36. ergotamin$.mp. 37. dihydroergotamin$.mp. 38. DHE.mp. 39. opioid$.mp. 40. opium.mp. 41. methadon$.mp. 42. meperidine.mp. 43. butorphanol.mp. 44. hydromorphon$.mp. 45. morphin$.mp. 46. codein?.mp. 47. butalbital.mp. 48. pentazocine.mp. 49. propoxyphene.mp. 50. nalbuphine.mp. 51. oxycodon$.mp. 52. ocymorphon$.mp. 53. alfentanil.mp. 54. fentanyl.mp. 55. sufentanil.mp. 56. caffeine.mp. 57. "combination analgesic?".tw. 58. tryptamines.mp. 59. triptan?.mp. 60. sumatriptan.mp. 61. naratriptan.mp. 62. rizatriptan.mp. 63. zolmitriptan.mp. 64. almotriptan.mp. 65. eletriptan.mp. 66. frovatriptan.mp. 67. serotonin agonist?.mp. 68. ((5‐hydroxytriptamine or 5‐HT) adj2 agonist?).mp. 69. (antiemetic? or anti‐emetic?).mp. [mp=title, abstract, original title, name of substance word, subject heading word, keyword heading word, protocol supplementary concept word, rare disease supplementary concept word, unique identifier] 70. (antinauseant? or anti‐nauseant?).mp. 71. thiethylperazin$.mp. 72. trimethobenzamid$.mp. 73. scopolamin$.mp. 74. chlorpromazine.mp. 75. prochlorperazine.mp. 76. promethazin$.mp. 77. perphenazin$.mp. 78. trifluoperazin$.mp. 79. met#clopr#mide.mp. 80. ondansetron.mp. 81. granisetron.mp. 82. dolasetron.mp. 83. diphenhydramine.mp. 84. hydroxyzine.mp. 85. dimenhydrinate.mp. 86. dronabinol.mp. 87. nabilone.mp. 88. fluid bolus.mp. 89. normal saline.mp. 90. magnesium.mp. 91. lidocaine.mp. 92. corticosteroid$.mp. 93. prednisolone.mp. 94. solumedrol.mp. 95. dexamethason$.mp. 96. hydrocortisol.mp. 97. exp methylprednisolone/ 98. Botulinum Toxin Type A/ 99. botulinium toxin.mp. 100. botox.mp. 101. oxygen.mp. 102. clonidine.mp. 103. diflunisal.mp. 104. (levomethadyl or levo‐methadyl).mp. 105. remifentanil.mp. 106. ziconotid$.mp. 107. placebo$.mp. 108. (antimigrain$ or anti‐migrain$).mp. 109. divalproex.mp. 110. methysergid$.mp. 111. (ergoloid adj1 mesylate$).mp. 112. (abortive adj3 (therap$ or treatment$)).mp. 113. or/6‐112 114. and/5,113 115. clinical trial.pt. 116. randomized controlled trial.pt. 117. randomi?ed.ti,ab. 118. placebo.ti,ab. 119. dt.fs. 120. randomly.ti,ab. 121. trial.ti,ab. 122. groups.ti,ab. 123. or/115‐122 124. animals/ 125. humans/ 126. 124 not (124 and 125) 127. 123 not 126 128. exp Infant/ 129. exp Child/ 130. Adolescent/ 131. Minors/ 132. exp Puberty/ 133. exp Pediatrics/ 134. infant$.mp. 135. infancy.mp. 136. newborn$.mp. 137. baby.mp. 138. babies.mp. 139. neonat$.mp. 140. preterm$.mp. 141. prematur$.mp. 142. postmatur$.mp. 143. child$.mp. 144. kid.mp. 145. kids.mp. 146. toddler$.mp. 147. adolescen$.mp. 148. teen$.mp. 149. boy$.mp. 150. girl.mp. 151. minor$.mp. 152. pubert$.mp. 153. pubescen$.mp. 154. prepubescen$.mp. 155. pediatric$.mp. 156. paediatric$.mp. 157. peadiatric$.mp. 158. or/128‐156 159. and/114,127,158 160. limit 159 to ed=20141219‐20161231 161. remove duplicates from 160