Migraine related terms: 1. exp Headache Disorders/ 2. vascular headaches/ 3. headache/ 4. (migraine$ or headache$ or head‐ache$ or cephalgia or cephalalgia).ti,ab.

5. or/1‐4 (70,483)

Pharmaceutical related terms: 6. exp Drug Therapy/ 7. (ad or ae or dt or to).fs. 8. exp Treatment Outcome/ 9. exp Analgesics/ 10. "nonsteroidal anti‐inflammatory agent?".mp. 11. "non‐steroidal anti‐inflammatory agent?".mp. 12. NSAID?.mp. 13. ibuprofen.mp. 14. fenoprofen.mp. 15. flurbiprofen.mp. 16. ketoprofen.mp. 17. ketorolac.mp. 18. diclofenac.mp. 19. etodolac.mp. 20. sulindac.mp. 21. naproxen.mp. 22. tolmetin.mp. 23. oxaprozin.mp. 24. tenoxicam.mp. 25. tiaprofenic acid.mp. 26. mefenamic acid.mp. 27. ((acetylsalicylic adj1.acid) or aspirin).mp. 28. piroxicam.mp. 29. celecoxib.mp. 30. meloxicam.mp. 31. indomethacin.mp. 32. floctafenin$.mp. 33. nabumeton$.mp. 34. acetaminophen.mp. 35. paracetamol.mp. 36. ergotamin$.mp. 37. dihydroergotamin$.mp. 38. DHE.mp. 39. opioid$.mp. 40. opium.mp. 41. methadon$.mp. 42. meperidine.mp. 43. butorphanol.mp. 44. hydromorphon$.mp. 45. morphin$.mp. 46. codein?.mp. 47. butalbital.mp. 48. pentazocine.mp. 49. propoxyphene.mp. 50. nalbuphine.mp. 51. oxycodon$.mp. 52. ocymorphon$.mp. 53. alfentanil.mp. 54. fentanyl.mp. 55. sufentanil.mp. 56. caffeine.mp. 57. "combination analgesic?".tw. 58. tryptamines.mp. 59. triptan?.mp. 60. sumatriptan.mp. 61. naratriptan.mp. 62. rizatriptan.mp. 63. zolmitriptan.mp. 64. almotriptan.mp. 65. eletriptan.mp. 66. frovatriptan.mp. 67. serotonin agonist?.mp. 68. ((5‐hydroxytriptamine or 5‐HT) adj2 agonist?).mp. 69. (antiemetic? or anti‐emetic?).mp. 70. (antinauseant? or anti‐nauseant?).mp. 71. thiethylperazin$.mp. 72. trimethobenzamid$.mp. 73. scopolamin$.mp. 74. chlorpromazine.mp. 75. prochlorperazine.mp. 76. promethazin$.mp. 77. perphenazin$.mp. 78. trifluoperazin$.mp. 79. met#clopr#mide.mp. 80. ondansetron.mp. 81. granisetron.mp. 82. dolasetron.mp. 83. diphenhydramine.mp. 84. hydroxyzine.mp. 85. dimenhydrinate.mp. 86. dronabinol.mp. 87. nabilone.mp. 88. fluid bolus.mp. 89. normal saline.mp. 90. magnesium.mp. 91. lidocaine.mp. 92. corticosteroid$.mp. 93. prednisolone.mp. 94. solumedrol.mp. 95. dexamethason$.mp. 96. hydrocortisol.mp. 97. exp methylprednisolone/ 98. Botulinum Toxin Type A/ 99. botulinium toxin.mp. 100. botox.mp. 101. oxygen.mp. 102. clonidine.mp. 103. diflunisal.mp. 104. (levomethadyl or levo‐methadyl).mp. 105. remifentanil.mp. 106. ziconotid$.mp. 107. placebo$.mp. 108. (antimigrain$ or anti‐migrain$).mp. 109. divalproex.mp. 110. methysergid$.mp. 111. (ergoloid adj1 mesylate$).mp. 112. (abortive adj3 (therap$ or treatment$)).mp.

113. or/6‐112 (4,457,175)

RCT filter: 114. and/5,113 (33,933) 115. randomized controlled trial.pt. 116. controlled clinical trial.pt. 117. randomized.ab. 118. placebo.ab. 119. clinical trials as topic.sh. 120. randomly.ab. 121. trial.ti. 122. or/115‐121 (762,426) 123. exp animals/ not humans.sh. (3,730,608)

124. 122 not 123 [Updated Cochrane RCT filter max specificity and precision] (702,878)

Child related terms: 125. exp Infant/ 126. exp Child/ 127. Adolescent/ 128. Minors/ 129. exp Puberty/ 130. exp Pediatrics/ 131. infant$.mp. 132. infancy.mp. 133. newborn$.mp. 134. baby.mp. 135. babies.mp. 136. neonat$.mp. 137. preterm$.mp. 138. prematur$.mp. 139. postmatur$.mp. 140. child$.mp. 141. kid.mp. 142. kids.mp. 143. toddler$.mp. 144. adolescen$.mp. 145. teen$.mp. 146. boy$.mp. 147. girl.mp. 148. minor$.mp. 149. pubert$.mp. 150. pubescen$.mp. 151. prepubescen$.mp. 152. pediatric$.mp. 153. paediatric$.mp. 154. peadiatric$.mp.

155. or/125‐154 (3,241,093)

156. and/114,124,155 [combination of migraine + drug terms + RCT filter + child filter] (2,844)

Date limits for update: 157. limit 156 to ed="20080101‐20120630" (639) 158. (2008* or 2009* or 201*).dp,ep,yr. [date of publication (.dp), electronic date of entry (.ep) and year (.yr) search fields for update] (3,078,760) 159. and/156,158 [application of date restrictions to search results] (599) 160. or/157,159 [combination of entry date and other date restrictions] (639)

Date limits for update 2013: 161. limit 156 to ed="20120630‐20130430" (90) 162. (2012 jun* or 2013*).dp,ep. [date of publication (.dp), electronic date of entry (.ep)] (95,823) 163. and/156,162 [application of date restrictions to search results] (12) 164. or/161,163 [combination of date restrictions] (90)