Migraine related terms: 1. (migraine$ or headache$ or head‐ache$ or cephalgia or cephalalgia).mp. (3,432)

Pharmaceutical related terms: 2. (drug adj3 (therap$ or treatment?)).mp. 3. ((anti‐migrain$ or antimigrain$) adj3 (therap$ or treatment?)).mp. 4. (treatment adj5.outcome).mp. 5. analgesi$.mp. 6. "nonsteroidal anti‐inflammatory agent?".mp. 7. "non‐steroidal anti‐inflammatory agent?".mp. 8. NSAID?.mp. 9. ibuprofen.mp. 10. fenoprofen.mp. 11. flurbiprofen.mp. 12. ketoprofen.mp. 13. ketorolac.mp. 14. diclofenac.mp. 15. etodolac.mp. 16. sulindac.mp. 17. diflunisal.mp. 18. naproxen.mp. 19. oxaprozin.mp. 20. tiaprofenic acid.mp. 21. mefenamic acid.mp. 22. indomethacin.mp. 23. tolmetin.mp. 24. celecoxib.mp. 25. meloxicam.mp. 26. piroxicam.mp. 27. tenoxicam.mp. 28. floctafenin$.mp. 29. nabumeton$.mp. 30. acetaminophen.mp. 31. paracetamol.mp. 32. ergot$ alkaloid?.mp. 33. ergotamin$.mp. 34. dihydroergotoxin$.mp. 35. dihydroergotamin$.mp. 36. DHE.mp. 37. ergoloid mesylates.mp. 38. methysergide.mp. 39. ziconotide.mp. 40. opioid$.mp. 41. opiate$.mp. 42. opium.mp. 43. meperidine.mp. 44. alfentan#l.mp. 45. fentan#l.mp. 46. rem#fentan#l.mp. 47. sufentan#l.mp. 48. levomethadyl.mp. 49. butorphanol.mp. 50. codein?.mp. 51. morphine.mp. 52. pentazocin$.mp. 53. (propoxyphen$ or dextro?propoxyphen$).mp. 54. nalbuphin$.mp. 55. hydromorphon$.mp. 56. oxycodon$.mp. 57. oxymorphon$.mp. 58. methadon$.mp. 59. butalbital.mp. 60. aspirin.mp. 61. acetylsalicylic acid.mp. 62. caffeine.mp. 63. "combination analgesic?".tw. 64. APAP.tw. 65. dichloralphenazone.mp. 66. isomethepten$.mp. 67. corticosteroid$.mp. 68. hydrocortisone.mp. 69. prednisolone.mp. 70. methylprednisolone.mp. 71. dexamethasone.mp. 72. tryptamin$.mp. 73. triptan?.mp. 74. sumatriptan.mp. 75. naratriptan.mp. 76. rizatriptan.mp. 77. zolmitriptan.mp. 78. almotriptan.mp. 79. eletriptan.mp. 80. frovatriptan.mp. 81. serotonin agonist?.mp. 82. ((5‐hydroxytryptamine or 5‐HT) adj2 agonist?).mp. 83. (antiemetic? or anti‐emetic?).mp. 84. (antinauseant? or anti‐nauseant?).mp. 85. chlorpromazine.mp. 86. prochlorperazine.mp. 87. perphenazine.mp. 88. trifluoperazine.mp. 89. (met#clopr#mide or metochlopramide).mp. 90. scopolamin$.mp. 91. dimenhydrinate.mp. 92. dronabinol.mp. 93. nabilon$.mp. 94. thiethylperazine.mp. 95. trimethobenzamide.mp. 96. ondansetron.mp. 97. granisetron.mp. 98. dolasetron.mp. 99. diphenhydramine.mp. 100. hydroxyzine.mp. 101. promethazine.mp. 102. Valproic Acid.mp. 103. valproate.mp. 104. divalproex sodium.mp. 105. Clonidine.mp. 106. fluid bolus.mp. 107. normal saline.mp. 108. magnesium.mp. 109. lidocaine.mp. 110. botulinium toxin.mp. 111. botox.mp. 112. oxygen.mp. 113. placebo$.mp.

114. or/2‐113 [migraine drugs] (50,953)

RCT filter: 115. randomized controlled trial.pt. 116. controlled clinical trial.pt. 117. randomized.ab. 118. placebo.ab. 119. randomly.ab. 120. trial.ti. 121. or/115‐120 (27,679) 122. exp animals/ not humans.sh. (1)

123. 121.not 122 [Cochrane RCT filter, slightly modified for database] (27,679)

124. and/1,114,123 [combination of migraine + drugs + RCT terms] (233)

Child related terms: 125. infant$.mp. 126. infancy.mp. 127. newborn$.mp. 128. baby.mp. 129. babies.mp. 130. neonat$.mp. 131. preterm$.mp. 132. prematur$.mp. 133. postmatur$.mp. 134. child$.mp. 135. kid.mp. 136. kids.mp. 137. toddler$.mp. 138. adolescen$.mp. 139. teen$.mp. 140. boy$.mp. 141. girl.mp. 142. girls.mp. 143. minor$.mp. 144. pubert$.mp. 145. pubescen$.mp. 146. pediatric$.mp. 147. paediatric$.mp. 148. peadiatric$.mp.

149. or/125‐148 [child filter] (66,612)

150. and/124,149 [migraine + drug + RCT + child] (29)

Date limits for update: 151. (2008* or 2009* or 201*).ed,ep,up,yr. [entry date, e‐pub date, update code, year of pub] (1,343,461) 152. 150 and 151 (29)

Date limits for update 2013: 153. ("2012" or "2013").ed,ep,up,yr. [entry date, e‐pub date, update code, year of pub] (471,980) 154. and/150,153 (16)