Migraine related terms: 1. exp Headache Disorders/ 2. vascular headaches/ 3. headache/ 4. (migraine$ or headache$ or head‐ache$ or cephalgia or cephalalgia).ti,ab.

5. or/1‐4 (8,180)

Pharmaceutical related terms: 6. exp Drug Therapy/ 7. (ad or ae or dt or to).fs. 8. exp Treatment Outcome/ 9. exp Analgesics/ 10. "nonsteroidal anti‐inflammatory agent?".mp. 11. "non‐steroidal anti‐inflammatory agent?".mp. 12. NSAID?.mp. 13. ibuprofen.mp. 14. fenoprofen.mp. 15. flurbiprofen.mp. 16. ketoprofen.mp. 17. ketorolac.mp. 18. diclofenac.mp. 19. etodolac.mp. 20. sulindac.mp. 21. naproxen.mp. 22. tolmetin.mp. 23. oxaprozin.mp. 24. tenoxicam.mp. 25. tiaprofenic acid.mp. 26. mefenamic acid.mp. 27. ((acetylsalicylic adj1 acid) or aspirin).mp. 28. piroxicam.mp. 29. celecoxib.mp. 30. meloxicam.mp. 31. indomethacin.mp. 32. floctafenin$.mp. 33. nabumeton$.mp. 34. acetaminophen.mp. 35. paracetamol.mp. 36. ergotamin$.mp. 37. dihydroergotamin$.mp. 38. DHE.mp. 39. opioid$.mp. 40. opium.mp. 41. methadon$.mp. 42. meperidine.mp. 43. butorphanol.mp. 44. hydromorphon$.mp. 45. morphin$.mp. 46. codein?.mp. 47. butalbital.mp. 48. pentazocine.mp. 49. propoxyphene.mp. 50. nalbuphine.mp. 51. oxycodon$.mp. 52. ocymorphon$.mp. 53. alfentanil.mp. 54. fentanyl.mp. 55. sufentanil.mp. 56. caffeine.mp. 57. "combination analgesic?".tw. 58. tryptamines.mp. 59. triptan?.mp. 60. sumatriptan.mp. 61. naratriptan.mp. 62. rizatriptan.mp. 63. zolmitriptan.mp. 64. almotriptan.mp. 65. eletriptan.mp. 66. frovatriptan.mp. 67. serotonin agonist?.mp. 68. ((5‐hydroxytriptamine or 5‐HT) adj2 agonist?).mp. 69. (antiemetic? or anti‐emetic?).mp. 70. (antinauseant? or anti‐nauseant?).mp. 71. thiethylperazin$.mp. 72. trimethobenzamid$.mp. 73. scopolamin$.mp. 74. chlorpromazine.mp. 75. prochlorperazine.mp. 76. promethazin$.mp. 77. perphenazin$.mp. 78. trifluoperazin$.mp. 79. met#clopr#mide.mp. 80. ondansetron.mp. 81. granisetron.mp. 82. dolasetron.mp. 83. diphenhydramine.mp. 84. hydroxyzine.mp. 85. dimenhydrinate.mp. 86. dronabinol.mp. 87. nabilone.mp. 88. fluid bolus.mp. 89. normal saline.mp. 90. magnesium.mp. 91. lidocaine.mp. 92. corticosteroid$.mp. 93. prednisolone.mp. 94. solumedrol.mp. 95. dexamethason$.mp. 96. hydrocortisol.mp. 97. exp methylprednisolone/ 98. Botulinum Toxin Type A/ 99. botulinium toxin.mp. 100. botox.mp. 101. oxygen.mp. 102. clonidine.mp. 103. diflunisal.mp. 104. (levomethadyl or levo‐methadyl).mp. 105. remifentanil.mp. 106. ziconotid$.mp. 107. placebo$.mp. 108. (antimigrain$ or anti‐migrain$).mp. 109. divalproex.mp. 110. methysergid$.mp. 111. (ergoloid adj1 mesylate$).mp. 112. (abortive adj3 (therap$ or treatment$)).mp.

113. or/6‐112 (335,914)

114. and/5,113 (6,616)

Child related terms: 115. exp Infant/ 116. exp Child/ 117. Adolescent/ 118. Minors/ 119. exp Puberty/ 120. exp Pediatrics/ 121. infant$.mp. 122. infancy.mp. 123. newborn$.mp. 124. baby.mp. 125. babies.mp. 126. neonat$.mp. 127. preterm$.mp. 128. prematur$.mp. 129. postmatur$.mp. 130. child$.mp. 131. kid.mp. 132. kids.mp. 133. toddler$.mp. 134. adolescen$.mp. 135. teen$.mp. 136. boy$.mp. 137. girl.mp. 138. minor$.mp. 139. pubert$.mp. 140. pubescen$.mp. 141. prepubescen$.mp. 142. pediatric$.mp. 143. paediatric$.mp. 144. peadiatric$.mp.

145. or/115‐144 (136,786)

146. and/114,145 [migraine + drugs + child] (2,107)

Removal of MEDLINE records: 147. limit 146 to medline records (1,954) 148. 146 not 147 (153)

Date limits for update: 149. (2008* or 2009* or 201*).up. (671,470) 150. and/148‐149 [application of update code limit] (153)

151. limit 148 to latest update (2) 152. (2012 jun* or 2013*).up. [update code limit] (27,314) 153. new.uf. [update flag for new articles] (30,970) 154. (152 or 153) and 148 [application of update code and update flag to results] (10) 155. or/151,154 [combination of update results] (10)