Migraine related terms: 1. exp Headache Disorders/ 2. vascular headache/ 3. headache/ 4. (migraine$ or headache$ or head‐ache$ or cephalgia or cephalalgia).ti,ab.

5. or/1‐4 (188,282)

Pharmaceutical related terms: 6. exp Drug Therapy/ 7. (drug adj3 (therap$ or treatment?)).mp. 8. ((anti‐migrain$ or antimigrain$) adj3 (therap$ or treatment?)).mp. 9. (ad or ae or dt or to).fs. 10. exp Treatment Outcome/ 11. exp Analgesics/ 12. "nonsteroidal anti‐inflammatory agent?".mp. 13. "non‐steroidal anti‐inflammatory agent?".mp. 14. NSAID?.mp. 15. ibuprofen.mp. 16. fenoprofen.mp. 17. flurbiprofen.mp. 18. ketoprofen.mp. 19. ketorolac.mp. 20. diclofenac.mp. 21. etodolac.mp. 22. sulindac.mp. 23. diflunisal.mp. 24. naproxen.mp. 25. oxaprozin.mp. 26. tiaprofenic acid.mp. 27. mefenamic acid.mp. 28. indomethacin.mp. 29. tolmetin.mp. 30. celecoxib.mp. 31. meloxicam.mp. 32. piroxicam.mp. 33. tenoxicam.mp. 34. floctafenin$.mp. 35. nabumeton$.mp. 36. acetaminophen.mp. 37. paracetamol.mp. 38. ergot$ alkaloid?.mp. 39. ergotamin$.mp. 40. dihydroergotoxin$.mp. 41. dihydroergotamin$.mp. 42. DHE.mp. 43. ergoloid mesylates.mp. 44. methysergide.mp. 45. ziconotide.mp. 46. opioid$.mp. 47. opiate$.mp. 48. opium.mp. 49. meperidine.mp. 50. alfentan#l.mp. 51. fentan#l.mp. 52. rem#fentan#l.mp. 53. sufentan#l.mp. 54. levomethadyl.mp. 55. butorphanol.mp. 56. codein?.mp. 57. morphine.mp. 58. pentazocin$.mp. 59. (propoxyphen$ or dextro?propoxyphen$).mp. 60. nalbuphin$.mp. 61. hydromorphon$.mp. 62. oxycodon$.mp. 63. oxymorphon$.mp. 64. methadon$.mp. 65. butalbital.mp. 66. aspirin.mp. 67. acetylsalicylic acid.mp. 68. caffeine.mp. 69. "combination analgesic?".tw. 70. APAP.tw. 71. dichloralphenazone.mp. 72. isomethepten$.mp. 73. corticosteroid$.mp. 74. hydrocortisone.mp. 75. prednisolone.mp. 76. methylprednisolone.mp. 77. dexamethasone.mp. 78. tryptamin$.mp. 79. triptan?.mp. 80. sumatriptan.mp. 81. naratriptan.mp. 82. rizatriptan.mp. 83. zolmitriptan.mp. 84. almotriptan.mp. 85. eletriptan.mp. 86. frovatriptan.mp. 87. serotonin agonist?.mp. 88. ((5‐hydroxytryptamine or 5‐HT) adj2 agonist?).mp. 89. (antiemetic? or anti‐emetic?).mp. 90. (antinauseant? or anti‐nauseant?).mp. 91. chlorpromazine.mp. 92. prochlorperazine.mp. 93. perphenazine.mp. 94. trifluoperazine.mp. 95. (met#clopr#mide or metochlopramide).mp. 96. scopolamin$.mp. 97. dimenhydrinate.mp. 98. dronabinol.mp. 99. nabilon$.mp. 100. thiethylperazine.mp. 101. trimethobenzamide.mp. 102. ondansetron.mp. 103. granisetron.mp. 104. dolasetron.mp. 105. diphenhydramine.mp. 106. hydroxyzine.mp. 107. promethazine.mp. 108. Valproic Acid.mp. 109. valproate.mp. 110. divalproex sodium.mp. 111. Clonidine.mp. 112. fluid bolus.mp. 113. normal saline.mp. 114. magnesium.mp. 115. lidocaine.mp. 116. Botulinum Toxin Type A/ 117. botulinium toxin.mp. 118. botox.mp. 119. oxygen.mp. 120. placebo$.mp.

121. or/6‐120 [combination of all possible pharmaceutical treatments for migraine] (5,743,355)

RCT filter: 122. random*.tw. 123. placebo*.mp. 124. double‐blind*.tw.

125. or/122‐124 [RCT filter from J Med Libr Assoc 2006] (907,731)

Child related terms: 126. adolescent/ 127. child/ 128. newborn/ 129. exp Pediatrics/ 130. infant$.mp. 131. infancy.mp. 132. newborn$.mp. 133. baby.mp. 134. babies.mp. 135. neonat$.mp. 136. preterm$.mp. 137. prematur$.mp. 138. postmatur$.mp. 139. child$.mp. 140. kid.mp. 141. kids.mp. 142. toddler$.mp. 143. adolescen$.mp. 144. teen$.mp. 145. juvenile$.mp. 146. boy$.mp. 147. girl.mp. 148. girls.mp. 149. minor$.mp. 150. pubert$.mp. 151. pubescen$.mp. 152. pediatric$.mp. 153. paediatric$.mp. 154. peadiatric$.mp.

155. or/126‐154 [child filter as per original search]

156. and/5,121,125,155 [combination of migrain + drugs + RCT + child] (6,357)

157. (2008* or 2009* or 201*).dp,em,yr. [date of publication, entry date, year of publication limits] (4,936,810) 158. and/156‐157 [application of date limits] (2,884)

Update search limits for 2013: 159. (2012 jun* or 2013*).dp. [date of publication limit] (24,334) 160. (20122* or 20123* or 20124* or 20125* or 2013*).em. [entry date limit] (1,247,362) 161. (or/159‐160) and 156 [application of date limits] (508)