Summary of findings for the main comparison. Primary analysis: less versus more frequent for intravenous administration set replacement.
| Primary analysis: less versus more frequent for intravenous administration set replacement | ||||||
| Patient or population: patients with intravenous administration set replacement Settings: all acute care settings Intervention: primary analysis: less versus more frequent | ||||||
| Outcomes | Illustrative comparative risks | Relative effect (95% CI) | No. of participants (studies) | Quality of the evidence (GRADE) | Comments | |
| Assumed risk | Corresponding risk | |||||
|
More frequent AS replacement |
Less frequent AS replacement |
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|
Catheter‐related BSI as defined using criteria specified by Maki 2006; Mermel 2009; and O'Grady 2002 |
33 of 932 participants (3.5%) developed a catheter‐related BSI | 35 of 862 participants (4.1%) developed a catheter‐related BSI |
RR 1.06 (0.66 to 1.68) |
1794 (8 studies) |
⊕⊕⊝⊝ lowa,b | |
|
Infusate‐related BSI as defined using criteria specified by O'Grady 2002 |
9 of 945 participants (0.95%) developed an infusate‐related BSI | 11 of 902 participants (1.2%) developed an infusate‐related BSI | RR 0.69 (0.31 to 1.51) | 1847 (11 studies) | ⊕⊕⊝⊝ lowa,b | |
|
Infusate colonization any positive quantitative culture of infusate |
27 infusates, of a total of 808 (3.3%), were colonized | 29 infusates, of a total of 741 (3.9%), were colonized | RR 1.15 (0.7 to 1.86) | 1549 (8 studies) | ⊕⊕⊝⊝ lowa,b | |
|
Catheter colonization any positive semiquantitative or quantitative culture from the distal catheter segment |
240 catheters, of a total of 717 (33.4%), were colonized | 266 catheters, of a total of 731 (36.4%), were colonized | RR 1.08 (0.94 to 1.24) | 1448 (4 studies) | ⊕⊕⊕⊝ moderatea | |
|
All‐cause BSI any positive blood culture drawn from a peripheral vein taken whilst the IVD is in situ, or within 48 hours of removal (O'Grady 2002) |
82 of 1135 participants (7.2%) developed a BSI from any cause | 69 of 1162 participants (5.9%) developed a BSI from any cause | RR 0.82 (0.48 to 1.4) | 2297 (6 studies) | ⊕⊕⊝⊝ lowa,b | |
| Mortality | 11 of 303 neonatal ICU participants died (3.6%) during their admission to the hospital | 77 of 1052 neonatal ICU participants died (7.3%) during their admission to the hospital | RR 1.85 (1.01 to 3.38) | 1355 (2 studies) | ⊕⊕⊝⊝ lowa,c | |
| CI: confidence interval; RR: risk ratio. | ||||||
| GRADE Working Group grades of evidence: High quality: Further research is very unlikely to change our confidence in the estimate of effect. Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate. Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate. Very low quality: We are very uncertain about the estimate. | ||||||
aThe proportion of information from studies at high or unclear risk of bias is sufficient to affect the interpretation of results. bBecause of the low rate of events and the wide confidence intervals of all studies. cStudies included were undertaken in a specific subgroup; not able to generalize results outside of this subgroup.