McLane 1998.

Methods	Randomized controlled trial
Participants	76 people with 49 arterial lines and/or 55 pulmonary artery catheters
Interventions	48 or 72 hour AS use
Outcomes	Infusate colonization IR‐BSI Catheter colonization－tip (distal) and hub (proximal) CR‐BSI
Notes	Nil exclusions No ITT
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Adequate random sequence generation Quote: "After informed consent was obtained, subjects were randomly allocated by coin toss to one of the following two groups" (p. 206)
Allocation concealment (selection bias)	Low risk	Coin toss after each participant would be adequate to conceal allocation
Blinding (performance bias and detection bias) All outcomes	Unclear risk	Not discussed, not feasible because of study design
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Not discussed, not feasible because of study design
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Outcome blinding possible but not discussed
Incomplete outcome data (attrition bias) All outcomes	High risk	Inadequate attrition data provided: not reported how many participants were screened, consented or were eliminated Quote: "Noncompliance with frequency of solution, stopcock or tubing changes, early catheter removal, or failure to obtain appropriate cultures eliminated the subjects from the study. Subject attrition was handled by entering another subject into the study" (p. 206)
Selective reporting (reporting bias)	Low risk	No pre‐protocol
Other bias	Unclear risk	Quote: "Specimens were obtained for culture before each flush solution change per group assignment (48 or 72 h)" (p. 206) More frequent outcome measurements in 48 hour group