Raad 2001.

Methods	Randomized controlled trial
Participants	428 cancer patients requiring IV therapy. Tertiary university cancer centre, USA
Interventions	Administration set changes at 72 or 96 to 168 hours
Outcomes	Infusate colonization IR‐BSI CR‐BSI
Notes	Exclusions: not stated Central catheters: 100% PN: Data from PN participants couldn't be used, as they included participants receiving blood Loss to follow‐up: not stated
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Adequate random sequence generation Quote: "prospective randomized study" (abstract) Quote: "computer‐generated randomization list" (p. 136‐7)
Allocation concealment (selection bias)	Unclear risk	Not discussed
Blinding (performance bias and detection bias) All outcomes	Unclear risk	Not discussed, not feasible because of study design
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Not discussed, not feasible because of study design
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Outcome blinding possible but not discussed
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	No mention of any missing data or attrition
Selective reporting (reporting bias)	Unclear risk	No pre‐protocol Stopped early (n = 512) after interim analysis showed 3 IR‐BSI in 96 to 167 hour group (P = 0.09)
Other bias	Unclear risk	Outcome definition of contaminated tip was ≥ 10 cfu