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Trial Sequential Analysis for variceal rebleeding episodes at 30 days is calculated based on control event rate of 12%; a RRR of 20%; a type I error of 2.5%, a type II error of 10%; and diversity of 0%. The DARIS of 8304 was not achieved and Z‐curve did not cross the alpha‐spending boundary (RR 0.18, alpha‐spending boundary‐adjusted CI 0.00 to 10.31).
