CENTRAL	PubMed	EMBASE (Ovid)
1 MESH DESCRIPTOR Epistaxis EXPLODE ALL AND CENTRAL:TARGET 2 (epistax* OR nosebleed* OR rhinorrhag* OR rhinorrhaeg*):AB,EH,KW,KY,MC,MH,TI,TO AND CENTRAL:TARGET 3 #1 OR #2 AND CENTRAL:TARGET 4 MESH DESCRIPTOR Nose EXPLODE ALL AND CENTRAL:TARGET 5 (nose OR nasal):AB,EH,KW,KY,MC,MH,TI,TO AND CENTRAL:TARGET 6 #4 OR #5 AND CENTRAL:TARGET 7 MESH DESCRIPTOR Hemorrhage EXPLODE ALL AND CENTRAL:TARGET 8 (hemorrhag* OR haemorrhag* OR bleed* OR bloodloss*):AB,EH,KW,KY,MC,MH,TI,TO AND CENTRAL:TARGET 9 (blood NEAR loss*):AB,EH,KW,KY,MC,MH,TI,TO AND CENTRAL:TARGET 10 #7 OR #8 OR #9 AND CENTRAL:TARGET 11 #6 AND #10 AND CENTRAL:TARGET 12 #3 OR #11 AND CENTRAL:TARGET 13 MESH DESCRIPTOR Tranexamic Acid EXPLODE ALL AND CENTRAL:TARGET 14 MESH DESCRIPTOR Antifibrinolytic Agents AND CENTRAL:TARGET 15 (tranexamic OR amca OR AMCHA OR amchafibrin OR amikapron OR aminomethylcyclohexanecarbonic OR aminomethylcyclohexane carbonic OR aminomethylcyclohexanocarbonic):AB,EH,KW,KY,MC,MH,TI,TO AND CENTRAL:TARGET 16 (methylcyclohexane carboxylate OR aminomethylcyclohexanecarboxylicOR aminomethyl cyclohexane carboxylic OR aminomethyl cyclohexanecarboxylic OR aminomethylcyclohexane carboxylic OR aminomethylcyclohexanecarboxylic OR aminomethylcyclohexanocarboxylic OR aminomethylcyclohexanoic OR amstat OR anvitoff):AB,EH,KW,KY,MC,MH,TI,TO AND CENTRAL:TARGET 17 (cyclocapron OR cyclokapron OR cyklocapron OR cyklokapron OR exacyl OR frenolyse OR hexacapron OR hexakapron OR tranex OR tranexanic OR trans achma OR transamin OR transaminomethylcyclohexane carboxylic OR transexamic OR ugurol):AB,EH,KW,KY,MC,MH,TI,TO AND CENTRAL:TARGET 18 #13 OR #14 OR #15 OR #16 OR #17 AND CENTRAL:TARGET 19 #12 AND #18 AND CENTRAL:TARGET	#7 #3 AND #6 #6 #5 OR #4 #5 tranex* [tiab] OR amca [tiab] OR AMCHA [tiab] OR amchafibrin [tiab] OR amikapron [tiab] OR aminomethyl [tiab] OR (methylcyclohexane [tiab] AND carboxylate [tiab]) OR amstat [tiab] OR anvitoff [tiab] OR (cl [tiab] AND 65336 [tiab]) OR cl65336 [tiab] OR cyclocapron [tiab] OR [tiab] cyclokapron [tiab] OR cyklocapron [tiab] OR cyklokapron [tiab] OR exacyl [tiab] OR frenolyse [tiab] OR hexacapron [tiab] OR hexakapron [tiab] OR (trans [tiab] AND achma [tiab]) OR transamin* [tiab] OR ugurol [tiab]) #4 "Tranexamic Acid"[Mesh] #3 #1 OR #2 #2 (“nose” [Mesh] OR nose [ti] OR nasal [ti]) AND (“hemorrhag* [Mesh] OR haemorrhag* [tiab] OR bleed* [ti] OR bloodloss* [ti] OR (blood [ti] AND loss [ti])) #1 “Epistaxis” [Mesh] OR epistax* [tiab] OR nosebleed* [tiab] OR rhinorrhag* [tiab] OR rhinorrhaeg* [tiab]	1 *EPISTAXIS/ 2 (epistax* or nosebleed* or rhinorrhag* or rhinorrhaeg*).tw. 3 exp *NOSE/ 4 (nose or nasal).ti. 5 exp bleeding/ 6 (haemorrhag* or hemorrhag* or bleed* or bloodloss* or (blood and loss)).ti. 7 5 or 6 8 3 or 4 9 7 and 8 10 tranexamic acid/ 11 (tranex* or amca or AMCHA or amchafibrin or amikapron or aminomethyl or anvitofor or amstat or cl65336 or cyclocapron or cyclokapron or cyklocapron or cyklokapron or exacyl or frenolyse or hexacapron or hexakapron or transamin or ugurol).tw. 12 ((methylcyclohexane and carboxylate) or (cl and "65336") or (trans and achma)).tw. 13 10 or 11 or 12 14 1 or 2 or 9 15 13 and 14
CINAHL (EBSCO)	Web of Science (Web of Knowledge	Trial registries
S12 S8 and S11 S11 S9 or S10 S10 TX ((methylcyclohexane and carboxylate) or (cl and "65336") or (trans and achma)) S9 TX tranex* or amca or AMCHA or amchafibrin or amikapron or aminomethyl or anvitofor or amstat or cl65336 or cyclocapron or cyclokapron or cyklocapron or cyklokapron or exacyl or frenolyse or hexacapron or hexakapron or transamin or ugurol S8 S1 or S2 or S7 S7 (S3 or S4) and (S5 or S6) S6 TI (haemorrhag* or hemorrhag* or bleed* or bloodloss* or (blood and loss)) S5 (MH "Hemorrhage") S4 TI (nose OR nasal) S3 (MH "Nose") S2 TX (epistax* or nosebleed* or rhinorrhag* or rhinorrhaeg*) S1 (MH "Epistaxis")	#9 #8 AND #5 #8 #7 OR #6 #7 TS=((methylcyclohexane and carboxylate) or (cl and "65336") or (trans and achma)) #6 TS=(tranex* or amca or AMCHA or amchafibrin or amikapron or aminomethyl or anvitofor or amstat or cl65336 or cyclocapron or cyclokapron or cyklocapron or cyklokapron or exacyl or frenolyse or hexacapron or hexakapron or transamin or ugurol) #5 #4 OR #1 #4 #3 AND #2 #3 TI=(haemorrhag* or hemorrhag* or bleed* or bloodloss* or (blood and loss)) #2 TI=(nose OR nasal) #1 TS=(epistax* or nosebleed* or rhinorrhag* or rhinorrhaeg*)	ICTRP epistaxis OR nosebleed* OR nose AND bleed* OR nose AND haemorr* OR nose AND hemorr* OR nose AND bloodloss ClinicalTrials.gov (via CRS Web) (epistaxis OR nosebleed) AND (tranexamic OR amca OR amcha OR amchafibrin OR amikapron OR aminomethyl OR anvitoff OR amstat OR cyclocapron OR cyclokapron OR cyklocapron OR cyklokapron OR exacyl OR frenolyse OR hexacapron OR hexakapron OR transamin) AND Study design: interventional