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. 2018 Dec 31;2018(12):CD004328. doi: 10.1002/14651858.CD004328.pub3

NCT02930941.

Trial name or title Topical intranasal tranexamic acid for epistaxis in the emergency department
Methods Randomised, double‐blind, single‐centre, placebo‐controlled trial
Participants Adults (> 18) with anterior epistaxis
Interventions Intervention group: tranexamic acid (100 mg/1 mL) sprayed in to the affected nostril(s) via intranasal atomisation device; may repeat 2 doses in each affected nostril(s)
Comparator group: 0.9% sodium chloride (1 mL)
Outcomes Primary outcome measure:
 Time to control of bleeding (7 days)
 Secondary outcome measures:
 Length of stay in the emergency department
 Re‐bleeding within the first 24 hours
 Re‐bleeding within the first week
 Incidence of thromboembolic events (7 days)
 Incidence of drug‐related events (7 days)
Starting date February 2016
Contact information Principal investigator: Aimee Moulin MD, University of California, Davis (akmoulin@ucdavis.edu)
Notes Estimated study completion date: December 2019