Walkey 2011.

Methods	Single centre randomized controlled trial
Participants	33 adult patients (15 intervention; 18 control) receiving mechanical ventilation via an endotracheal tube for >48 hours Setting: USA, medical ICU
Interventions	Intervention: SmartCare/PS™ Control: weaning according to usual care
Outcomes	Duration of weaning assessed as the time from the initiation of weaning (randomization) to the time of successful extubation (defined as 48 hours free of mechanical ventilation) Hospital mortality Complications (death during wean, ventilator‐associated pneumonia during wean, self extubation, reintubation)
Notes	This trial was terminated early due to slow recruitment
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Online random number generator
Allocation concealment (selection bias)	Low risk	Opaque envelopes used
Incomplete outcome data (attrition bias) All outcomes	High risk	Study terminated early due to slow recruitment. Limited reporting of outcome data
Selective reporting (reporting bias)	Unclear risk	Study terminated early due to slow recruitment. Limited reporting of outcome data
Other bias	Unclear risk	Study terminated early due to slow recruitment
Blinding of participants and personnel (performance bias) All outcomes	High risk	Not possible due to nature of intervention
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Unable to confirm if outcome assessors were also involved in the daily care of patients