Fernandez 2013.

Methods	Multi‐centre randomized controlled trial
Participants	Adults 18 years of age or older with an anticipated duration of mechanical ventilation > 24 hours
Interventions	Intervention: ventilatory support performed by PAV at 80% assistance (PB 840‐plus) FiO2 and PEEP according to routine practice Control: assist‐control ventilation, tidal volume, FiO2 and PEEP set according to routine practice
Outcomes	Duration of mechanical ventilation Gas exchange Short term complications (barotrauma, ARDS, atelectasis and pneumonia) Weaning success weaning success defined as the composite end‐point: time to resume spontaneous ventilation, rate of extubation success, need for non‐invasive ventilation (NIV) as rescue therapy, and reintubation rate Length of ICU stay Length of hospital stay ICU, hospital, 60‐day mortality
Notes	NCT01204281