Summary of findings 2. Sedative compared with different dosage of the same sedative for children needing dental care.
| Sedative compared with different dosage of the same sedative for children needing dental care | |||
| Patient or population: children needing dental care Setting: hospital Intervention: sedative Comparison: different dosage of the same sedative | |||
| Outcomes | Number of participants (studies) | Certainty of the evidence (GRADE) | Comments |
| Any behavioural score ‐ Midazolam (any mode of delivery) |
394 (10) | ⊕⊝⊝⊝ VERY LOW1 | There is insufficient evidence to determine whether any specific dose of intranasal midazolam is effective There is weak evidence from two trials that oral midazolam at a dose of 0.5 mg/kg to 0.75 mg/kg is an effective sedative for children. However, one trial administered both nitrous oxide and midazolam so it is difficult to attribute benefit to midazolam alone |
| Any behavioural score ‐ Hydroxyzine |
30 (1) | ⊕⊝⊝⊝ VERY LOW1 | There is insufficient evidence to determine whether any specific dose of hydroxyzine is effective |
| GRADE Working Group grades of evidence High certainty: we are very confident that the true effect lies close to that of the estimate of the effect. Moderate certainty: we are moderately confident in the effect estimate: the true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different. Low certainty: our confidence in the effect estimate is limited: the true effect may be substantially different from the estimate of the effect. Very low certainty: we have very little confidence in the effect estimate: the true effect is likely to be substantially different from the estimate of effect. | |||
1Downgraded for risk of bias, inconsistency and/or imprecision.