Summary of findings 3. Sedative compared with a different sedative for children needing dental care.
| Sedative compared with a different sedative for children needing dental care | |||
| Patient or population: children needing dental care Setting: hospital Intervention: sedative Comparison: different sedative | |||
| Outcomes | Number of participants (studies) | Certainty of the evidence (GRADE) | Comments |
| Any behavioural score ‐ Chloral hydrate/hydroxyzine versus |
235 (6) | ⊕⊝⊝⊝ VERY LOW1 | No two studies evaluating the same intervention and comparison found the same effect. There is insufficient evidence to draw any conclusions |
| Any behavioural score ‐ Chloral hydrate/promethazine versus |
24 (1) | ⊕⊝⊝⊝ VERY LOW1 | |
| Any behavioural score ‐ Dexmedetomidine versus |
120 (2) | ⊕⊝⊝⊝ VERY LOW1 | |
| Any behavioural score ‐ Ketamine versus |
494 (8) | ⊕⊝⊝⊝ VERY LOW1 | |
| Any behavioural score ‐ Ketamine/midazolam versus |
27 (1) | ⊕⊝⊝⊝ VERY LOW1 | |
| Any behavioural score ‐ Midazolam (oral) versus |
654 (7) | ⊕⊝⊝⊝ VERY LOW1 | |
| Any behavioural score ‐ Midazolam (intravenous) versus |
70 (2) | ⊕⊝⊝⊝ VERY LOW1 | |
| Any behavioural score ‐ Midazolam (rectal) versus | 90 (1) | ⊕⊝⊝⊝ VERY LOW1 | |
| Any behavioural score ‐ Sevoflurane versus |
1140 (3) | ⊕⊝⊝⊝ VERY LOW1 | |
| GRADE Working Group grades of evidence High certainty: we are very confident that the true effect lies close to that of the estimate of the effect. Moderate certainty: we are moderately confident in the effect estimate: the true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different. Low certainty: our confidence in the effect estimate is limited: the true effect may be substantially different from the estimate of the effect. Very low certainty: we have very little confidence in the effect estimate: the true effect is likely to be substantially different from the estimate of effect. | |||
1Downgraded for risk of bias, inconsistency and/or imprecision.