| Methods |
RCT comparing etomidate (n = 12) and ketamine (n = 10) |
| Participants |
22 ICU patients |
| Interventions |
Etomidate 0.3 mg/kg versus ketamine 2 mg/kg |
| Outcomes |
Intubating conditions, haemodynamic response to intubation, total serum cortisol 5 min post‐induction, duration of mechanical ventilation, ICU length of stay, mortality |
| Notes |
Need more information. This was conference poster and no actual data is presented. Primary author and supervising author contacted by e‐mail. Waiting on response. Unable to include in analysis due to lack of data |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
Unclear risk |
"prospective, randomized, double blinded study" reported, but sequence generation and concealment not described |
| Allocation concealment (selection bias) |
Unclear risk |
"prospective, randomized, double blinded study" reported, but sequence generation and concealment not described |
| Incomplete outcome data (attrition bias)
Mortality |
Unclear risk |
No description of incomplete data. Impacts on risk estimates not possible to describe, but bias possible |
| Incomplete outcome data (attrition bias)
Adrenal Gland Dysfunction |
Unclear risk |
No description of incomplete data. Impacts on risk estimates not possible to describe, but bias possible |
| Incomplete outcome data (attrition bias)
Hospital LOS |
Low risk |
N/A |
| Incomplete outcome data (attrition bias)
ICU LOS |
Unclear risk |
No description of incomplete data. Impacts on risk estimates not possible to describe, but bias possible |
| Incomplete outcome data (attrition bias)
Duration of mechanical Ventillation |
Unclear risk |
No description of incomplete data. Impacts on risk estimates not possible to describe, but bias possible |
| Incomplete outcome data (attrition bias)
Vasopressor requirements |
Low risk |
N/A |
| Incomplete outcome data (attrition bias)
Organ Dysfunction |
Low risk |
N/A |
| Incomplete outcome data (attrition bias)
All outcomes |
Unclear risk |
No description of incomplete data. Impacts on risk estimates not possible to describe, but bias possible |
| Selective reporting (reporting bias) |
Low risk |
all relevant outcomes addressed |
| Blinding of participants and personnel (performance bias)
All outcomes |
Low risk |
"prospective, randomized, double blinded study" reported, but no further description |
| Blinding of outcome assessment (detection bias)
All outcomes |
Low risk |
"prospective, randomized, double blinded study" reported. Exact nature of double blinding not fully specified, so effects on measurement remain unknown |
