Comparison 7. Prolonged feeding: partially hydrolysed formula versus cow's milk formula.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 All allergic disease	8		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
1.1 Infancy (incidence)	8	1820	Risk Ratio (M‐H, Fixed, 95% CI)	0.89 [0.77, 1.04]
1.2 Childhood (incidence)	2	510	Risk Ratio (M‐H, Fixed, 95% CI)	0.86 [0.67, 1.10]
2 Asthma	7		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
2.1 Infancy (incidence)	4	268	Risk Ratio (M‐H, Fixed, 95% CI)	0.54 [0.28, 1.04]
2.2 Childhood (incidence)	1	78	Risk Ratio (M‐H, Fixed, 95% CI)	0.38 [0.08, 1.84]
2.3 Childhood (prevalence)	3	789	Risk Ratio (M‐H, Fixed, 95% CI)	1.05 [0.80, 1.38]
3 Eczema	9		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
3.1 Infancy (incidence)	8	1699	Risk Ratio (M‐H, Fixed, 95% CI)	0.98 [0.82, 1.16]
3.2 Childhood (incidence)	2	510	Risk Ratio (M‐H, Fixed, 95% CI)	0.85 [0.61, 1.19]
3.3 Childhood (prevalence)	3	788	Risk Ratio (M‐H, Fixed, 95% CI)	0.92 [0.69, 1.22]
4 Rhinitis	5		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
4.1 Infancy (incidence)	3	206	Risk Ratio (M‐H, Fixed, 95% CI)	0.4 [0.09, 1.70]
4.2 Childhood (incidence)	1	78	Risk Ratio (M‐H, Fixed, 95% CI)	0.48 [0.04, 5.03]
4.3 Childhood (prevalence)	2	357	Risk Ratio (M‐H, Fixed, 95% CI)	0.97 [0.66, 1.41]
5 Food allergy	2		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
5.1 Infancy (incidence)	2	429	Risk Ratio (M‐H, Fixed, 95% CI)	1.53 [0.93, 2.49]
6 Cow's milk allergy	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
6.1 Infancy (incidence)	1	338	Risk Ratio (M‐H, Fixed, 95% CI)	2.31 [0.24, 21.97]