Comparison 8. Prolonged feeding: extensively hydrolysed formula versus cow's milk formula.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 All allergic disease	3		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
1.1 Infancy (incidence)	2	1561	Risk Ratio (M‐H, Fixed, 95% CI)	0.87 [0.68, 1.13]
1.2 Childhood (incidence)	1	651	Risk Ratio (M‐H, Fixed, 95% CI)	0.89 [0.71, 1.13]
1.3 Childhood (prevalence)	1	62	Risk Ratio (M‐H, Fixed, 95% CI)	1.76 [0.76, 4.09]
2 Asthma	3		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
2.1 Infancy (incidence)	1	96	Risk Ratio (M‐H, Fixed, 95% CI)	0.61 [0.18, 2.04]
2.2 Childhood (prevalence)	2	713	Risk Ratio (M‐H, Fixed, 95% CI)	1.15 [0.76, 1.72]
3 Eczema	4		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
3.1 Infancy (incidence)	3	1726	Risk Ratio (M‐H, Fixed, 95% CI)	0.83 [0.63, 1.08]
3.2 Childhood (incidence)	1	651	Risk Ratio (M‐H, Fixed, 95% CI)	0.86 [0.63, 1.17]
3.3 Childhood (prevalence)	2	713	Risk Ratio (M‐H, Fixed, 95% CI)	0.61 [0.39, 0.97]
4 Rhinitis	2		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
4.1 Infancy (incidence)	1	96	Risk Ratio (M‐H, Fixed, 95% CI)	2.76 [0.12, 66.22]
4.2 Childhood (prevalence)	1	62	Risk Ratio (M‐H, Fixed, 95% CI)	1.32 [0.53, 3.26]
5 Food allergy	1		Risk Ratio (M‐H, Fixed, 95% CI)	Subtotals only
5.1 Infancy (incidence)	1	96	Risk Ratio (M‐H, Fixed, 95% CI)	1.15 [0.33, 4.02]