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. 2018 Oct 19;2018(10):CD003664. doi: 10.1002/14651858.CD003664.pub6

Comparison 14. Prolonged feeding: partially hydrolysed casein‐containing formula versus cow's milk formula.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 All allergic disease 2   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
1.1 Infancy (incidence) 1 91 Risk Ratio (M‐H, Fixed, 95% CI) 1.36 [0.80, 2.31]
1.2 Childhood (prevalence) 1 62 Risk Ratio (M‐H, Fixed, 95% CI) 1.76 [0.76, 4.09]
2 Asthma 2   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
2.1 Infancy (incidence) 1 91 Risk Ratio (M‐H, Fixed, 95% CI) 0.34 [0.07, 1.60]
2.2 Childhood (prevalence) 1 62 Risk Ratio (M‐H, Fixed, 95% CI) 2.20 [0.77, 6.26]
3 Eczema 2   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
3.1 Infancy (incidence) 1 91 Risk Ratio (M‐H, Fixed, 95% CI) 1.30 [0.66, 2.55]
3.2 Childhood (prevalence) 1 62 Risk Ratio (M‐H, Fixed, 95% CI) 0.29 [0.03, 2.66]
4 Rhinitis 2   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
4.1 Infancy (incidence) 1 91 Risk Ratio (M‐H, Fixed, 95% CI) 0.0 [0.0, 0.0]
4.2 Childhood (prevalence) 1 62 Risk Ratio (M‐H, Fixed, 95% CI) 1.32 [0.53, 3.26]
5 Food allergy 1   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
5.1 Infancy (incidence) 1 91 Risk Ratio (M‐H, Fixed, 95% CI) 2.56 [0.86, 7.56]