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. 2018 Oct 19;2018(10):CD003664. doi: 10.1002/14651858.CD003664.pub6

Comparison 17. Prolonged feeding: extensively hydrolysed casein formula versus extensively hydrolysed whey formula.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 All allergic disease 2   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
1.1 Infancy (incidence) 2 1143 Risk Ratio (M‐H, Fixed, 95% CI) 0.96 [0.73, 1.26]
1.2 Childhood (incidence) 1 440 Risk Ratio (M‐H, Fixed, 95% CI) 0.68 [0.50, 0.90]
2 Asthma 2   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
2.1 Infancy (incidence) 1 161 Risk Ratio (M‐H, Fixed, 95% CI) 2.28 [0.83, 6.28]
2.2 Childhood (prevalence) 1 440 Risk Ratio (M‐H, Fixed, 95% CI) 0.71 [0.42, 1.19]
3 Eczema 2   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
3.1 Infancy (incidence) 2 1143 Risk Ratio (M‐H, Fixed, 95% CI) 0.81 [0.59, 1.10]
3.2 Childhood (incidence) 1 440 Risk Ratio (M‐H, Fixed, 95% CI) 0.62 [0.42, 0.92]
3.3 Childhood (prevalence) 1 440 Risk Ratio (M‐H, Fixed, 95% CI) 0.64 [0.33, 1.21]
4 Rhinitis 1   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
4.1 Infancy (incidence) 1 161 Risk Ratio (M‐H, Fixed, 95% CI) 2.08 [0.39, 11.02]
5 Food allergy 1   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
5.1 Infancy (incidence) 1 161 Risk Ratio (M‐H, Fixed, 95% CI) 1.45 [0.48, 4.39]
6 Cow's milk allergy 1   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
6.1 Infancy (incidence) 1 161 Risk Ratio (M‐H, Fixed, 95% CI) 5.19 [0.25, 106.38]
7 Urticaria 1   Risk Ratio (M‐H, Fixed, 95% CI) Subtotals only
7.1 Infancy (incidence) 1 161 Risk Ratio (M‐H, Fixed, 95% CI) 4.15 [0.47, 36.34]