Shoemaker 1986

Methods	n = 9, 1 centre Allocation concealment: local independent randomization Baseline similarity: age (D) Blinding: caregivers Cointerventions: not described Withdrawals: none Losses to follow‐up: none
Participants	Inclusions: Risk factor: sepsis or surgery; mechanical ventilation; CXR infiltrates, PaO2 < 55 mmHg on room air or P/F ratio < 250 mmHg, no evidence of volume overload
Interventions	Continuous IV PGE1, dose titrated to 30 ng/kg/minute (43.2 mcg/kg/day) for 48‐72 hours, or placebo
Outcomes	Mortality: RR 0.80 (95% CI 0.52 to 1.24)
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment (selection bias)	Low risk	A ‐ Adequate