Steinberg 1990

Methods	n = 10, 1 centre Allocation concealment: not described Baseline similarity: age Blinding: caregivers blinded; investigators not blinded Cointerventions: not described Withdrawals: none Losses to follow‐up: none
Participants	Inclusions: bilateral infiltrates on CXR, P/F ratio less than 200 mmHg, PEEP greater than 5 cmH20, PAOP less than or equal to 18 mmHg; duration of ventilation at least 24 hours Exclusions: chronic lung disease; pneumonia; gastrointestinal bleeding
Interventions	One dose of IV indomethacin 50 mg or placebo
Outcomes	Mortality: RR 0.50 (95% CI 0.06 to 3.91) Adverse events leading to discontinuation of therapy not reported Other safety data: no differences in levels of creatinine or blood urea nitrogen
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Allocation concealment (selection bias)	Unclear risk	B ‐ Unclear