| Trial name or title | Late Steroid Rescue Study: The Efficacy of Corticosteroids as Rescue Therapy for the Late Phase of Acute Respiratory Distress Syndrome |
| Methods | |
| Participants | 180 patients meeting AECC criteria for ARDS, 7‐28 days from onset of ARDS, continuing to require mechanical ventilation |
| Interventions | Methylprednisolone 2 mg/kg bolus, then 0.5 mg/kg every 6 hours for 14 days, then 0.5 mg/kg every 12 hours for 7 days, followed by a taper; or placebo |
| Outcomes | 60 day mortality; ventilator‐free days to day 28; organ failure‐free days to day 28; reduction in markers of fibroproliferation and inflammation at day 7; adverse events |
| Starting date | 1997 |
| Contact information | Study chair: Leonard Hudson MD, Harborview Medical Center, Seattle WA USA; njschwab@u.washington.edu |
| Notes | 1) Enrolment terminated; preliminary results presented at American Thoracic Society International Conference, 25 May 2004 2) Study protocol available at http://www.ardsnet.org/ards02.php (accessed 20 April 2004) |
Abbreviations: AECC = American‐European Consensus Conference (Bernard 1994), ALI = acute lung injury, ARDS = acute respiratory distress syndrome