Brinkmann 1998.

Methods	Study design: parallel RCT Study duration: not reported Study follow‐up: 24 h
Participants	Country: Germany Setting: single centre Inclusion criteria: elective infrarenal aortic surgery Number: treatment group (67); control group (64) Mean age ± SD (years): treatment group (13 ± 2); control group (13 ± 3) Sex (M/F): treatment group (11/2); control group (11/2) Exclusion criteria: NSAID medication at least 7 days prior to surgery; history of significant renal disease; evidence for renal artery stenosis on preoperative aortography.
Interventions	Treatment group Ibuprofen: 400 mg IV before skin incision Control group Placebo: aliquot IV before skin incision
Outcomes	CrCl, and fractional sodium excretion before surgery, 1 h after cross‐clamping, 6 h after cross‐clamping and 24 h after cross‐clamping (on the 1st postoperative day).
Notes	Funding Source: not reported Furosemide was given in post‐operative period in 5 patients (treatment group 3/13, control group 2/13), indication for administration unclear.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Study was described as randomised, method of randomisation was not reported
Allocation concealment (selection bias)	Unclear risk	Insufficient information to permit judgement
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Insufficient information to permit judgement
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Insufficient information to permit judgement
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Insufficient information to permit judgement
Selective reporting (reporting bias)	Low risk	All intended measurements were reported at baseline, 1 and 6 hours after cross‐clamping, and on the first POD
Other bias	Unclear risk	The study was conducted by the anaesthetics department of the University of Ulm. There is no mention of funding sources