Eljezi 2017.

Methods	Study design: parallel RCT Study duration: not reported Study follow‐up: 48 h
Participants	Country: France Setting: inpatient Inclusion criteria: patients undergoing elective open heart surgery or coronary artery bypass grafting Number: treatment group 1 (25); treatment group 2 (25); treatment group 3 (24) control group (23) Mean age ± SD (years): treatment group 1 (63 ± 9); treatment group 2 (63. ± 7); treatment group 3 (60 ± 11); control group (58 ± 13) Sex (M/F): treatment group 1 (23/2); treatment group 2 (22/3); treatment group 3 (24/0) control group (12/11) Exclusion criteria: kidney insufficiency defined as a CrCl < 60 mL/min‐1; hepatic insufficiency; congestive heart failure with ejection fraction < 45%; history of gastric peptic ulcer or GI bleeding; DM needing insulin therapy; preoperative coagulation disorder; allergy to NSAID; pregnancy or breastfeeding
Interventions	Treatment group 1 IV ketoprofen: 0.5 mg/kg every 6 h for 48 h Treatment group 2 IV ketoprofen 0.25 mg/kg every 6 h for 48 h Treatment group 3 IV ketoprofen: 0.125 mg/kg every 6 h for 48 h Control group IV normal saline
Outcomes	Pre‐operative SCr then SCr level at POD 1 and POD 2 Urine output every 4 h until 48 h post‐operatively
Notes	Only 48 h SCr and urine output results documented 100 patients randomised, 97 patient analysed
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Study was described as randomised, method of randomisation was not reported
Allocation concealment (selection bias)	Low risk	Allocation was concealed in an envelope
Blinding of participants and personnel (performance bias) All outcomes	Low risk	The study drug was prepared by an anaesthetist nurse not involved of post‐operative care, under the control of the anaesthetist in charge of the patient, who opened the allocation envelope
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Insufficient information to permit judgement
Incomplete outcome data (attrition bias) All outcomes	Low risk	There is no incomplete data
Selective reporting (reporting bias)	High risk	Methods state 4 hourly urinary output measurements until 48 h post‐operatively and SCr measurement for POD 1 and POD 2. No urinary output results documented for 0 – 44 h. SCr documented at baseline and a percentage rise at 48 h reported. No results for POD 1 reported
Other bias	Low risk	The study was conducted by the Department of Anesthesiology (Medecine Peri‐Operatoire) and the Clinical Pharmacology centre (CPC‐CIC) of the University Hospital of Clermont‐Ferrand (CHU Clermont‐Ferrand), France. The sponsorship was limited to supplies and expenses. The sponsorship included payment for employees for study design, patient’s inclusion, data entry, and analysis of the data. They also provided the study drugs at no cost. They had no influence or interference after the protocol was designed