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. 2018 Nov 29;2018(11):CD011274. doi: 10.1002/14651858.CD011274.pub2

McCrory 2002.

Methods

  • Study design: parallel RCT

  • Study duration: not reported

  • Study follow‐up: until 72 h post follow‐up from ICU
Participants

  • Country: Ireland

  • Setting: single centre

  • Inclusion criteria: elective thoracic surgery via thoracotomy

  • Number

    • Spinal: treatment group 1 (10); treatment group 2 (10); control group (10)

    • Epidural: treatment group 1 (5); treatment group 2 (5); control group (5)

  • Mean age ± SD (years)

    • Spinal: treatment group 1 (64 ± 4), treatment group 2 (63 ± 2), control (62 ± 2)

    • Epidural: treatment group 1 (58 ± 6), treatment group 2 (56 ± 8), control (66 ± 3)

  • Sex (M/F)

    • Spinal: treatment group 1 (6/4); treatment group 2 (5/5); control group (6/4)

    • Epidural: treatment group 1 (3/2); treatment group 2 (3/2); control group (3/2)

  • Exclusion criteria: history of peptic ulcer disease; renal and hepatic dysfunction; psychiatric illness; any chronic pain syndrome; and consumption of NSAIDs, corticosteroids, or any other drug known to interfere with prostaglandin production for 14 days before surgery.
Interventions Two types of administration ‐ spinal and epidural. Each were assigned to following 3 groups
Treatment group 1

  • Nimesulide: 100 mg twice daily


Treatment group 2

  • Ibuprofen: 400 mg 4 times daily


Control group

  • No NSAIDs or placebo
Outcomes

  • 24 h urinary creatinine
Notes

  • Funding Source: Baggott Street Hospital Academic Research Grant
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Study was described as randomised, method of randomisation was not reported.
Allocation concealment (selection bias) Unclear risk Insufficient information to permit judgement
Blinding of participants and personnel (performance bias) 
 All outcomes High risk Open‐label study
Blinding of outcome assessment (detection bias) 
 All outcomes Low risk Anaesthetists and patients did have knowledge of the study and allocated treatment group. This knowledge is unlikely to influence the primary renal outcome; 24 hour urinary creatinine
Nursing staff was unaware of patients participating in the study and will therefore not impact on the pain score outcomes presented
Incomplete outcome data (attrition bias) 
 All outcomes Unclear risk Insufficient information to permit judgement
Selective reporting (reporting bias) Low risk Study protocol matches outcomes presented
Other bias Low risk Study conducted in a university teaching hospital, non‐profit academic research grand received