NAFARM 2011.

Methods	Study design: parallel RCT Study duration: 2005 to 2009 Study follow‐up: until hospital discharge
Participants	Country: Brazil Setting: single centre Inclusion criteria: patients undergoing coronary artery bypass graft surgery Number: treatment group (82); control group (79) Mean age ± SD (years): treatment group (59.7 ± 9.8); control group (58.0 ± 8.6) Sex (M/F): treatment group (50/32); control group (52/27) Exclusion criteria: allergies to study medication; pregnant; off‐pump surgery; history of GI bleeding; chronic liver disease; kidney insufficiency (SCr > 132.6 mol/L); thrombocytopenia; reported preoperative use of glucocorticoids; previous diagnosis of atrial fibrillation
Interventions	Treatment group Naproxen: 275 mg twice/d for 5 days from the moment the patients returned to the ICU post surgery Control group Placebo: twice/d for 5 days from the moment the patients returned to the ICU post surgery
Outcomes	Kidney failure (SCr elevation ≥ 50% from baseline) Death Length of hospital stay
Notes	Funding source: no funding received
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	"The pharmacist made the randomization list and allocated the placebo and naproxen pills without the knowledge of any other person"
Allocation concealment (selection bias)	Low risk	Sealed envelope, medication appears identical, nursing staff giving out drugs are not part of the investigation team
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Sealed envelope, medication appears identical, nursing staff giving out drugs are not part of the investigation team
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Sealed envelope, medication appears identical, nursing staff giving out drugs are not part of the investigation team
Incomplete outcome data (attrition bias) All outcomes	Low risk	Results of all 161 randomised patients reported for primary and secondary outcomes
Selective reporting (reporting bias)	Low risk	Study protocol matches outcomes presented
Other bias	Low risk	The study appears to be free of other sources of bias