Puolakka 2009.

Methods	Study design: parallel RCT Study duration: not reported Study follow‐up: 20 h post‐operatively
Participants	Country: Finland Setting: single centre Inclusion criteria: patients undergoing laparoscopic hysterectomy Number: treatment group (15); control group (15) Mean age ± SD (years): treatment group (48.5 ± 7.9); control group (50.5 ± 4.5) Sex (M/F): All female Exclusion criteria: allergy to aspirin‐like drugs or sulphonamide; bronchial asthma; liver or kidney disturbances; peptic ulcer; bleeding disorder; pregnancy; substance abuse; chronic pain
Interventions	Treatment group Parecoxib: single dose of 80 mg IV, before the induction of anaesthesia Control group Saline
Outcomes	SCr and sensitive urine and serum markers for renal tubular injury directly after induction of anaesthesia, 2 h after induction, first and second POD
Notes	Post hoc analysis shows that study is underpowered to detect statistically significant serious adverse events Funding source: supported by the Medical Research Fund of Tampere University Hospital, Finland
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Computer generated randomisation
Allocation concealment (selection bias)	Low risk	Random numbers in opaque envelopes
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Nurse not involved in the study made up the study drugs
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Insufficient information to permit judgement
Incomplete outcome data (attrition bias) All outcomes	Low risk	No patients withdrawn. Missing data from 2 patients at variable time points. Missing outcome data balanced in numbers across intervention groups
Selective reporting (reporting bias)	Low risk	Study protocol matches outcomes presented
Other bias	Low risk	Non‐profit organisation funding received