Study	Reason for exclusion
Castiglione 1997	Wrong control group: control group also received ketorolac
Cheruku 2004	Wrong population: patients included with a SCr up to 2.0 mg/dL Insufficient post‐operative outcome measures reported; kidney function given for 3/100 patients only; all of those had a SCr above 2.0 mg/dL
Chow 2001	Wrong population: one third of patients underwent a nephrectomy; patients were excluded when a significant SCr rise was noted
Daniels 2014	Abstract‐only publication; no kidney function outcome measures documented
Doyle 1998	Wrong control group: patients randomised to 2 analgesic regimens
Fredman 1999	No relevant post‐operative kidney outcome measures
Grimsby 2012	Wrong population: patients with CKD were included and 111/128 patients underwent a nephrectomy
Hynes 2006	No relevant post‐operative kidney outcome measures
Leeson 2007	Kidney function parameters not clearly defined
Ma 2015	No kidney function parameters documented
Merry 2002	Wrong population: patients with CKD included
Nussmeier 2005	Included 6 (1%) of patients with kidney insufficiency. Post‐operative kidney failure or dysfunction reported at any time during the 30 days after surgery. No data given for the first 2 days after surgery
Nussmeier 2006	Patients were included when kidney disease was deemed significant by the investigator; 6 patients had kidney insufficiency (unknown eGFR) on randomisation. Adverse events were recorded. No SCr or urine output individually reported
Nuutinen 1991	No concise kidney outcome measures reported
Parker 1994	No concise kidney outcome measures reported
Rao 2000	Ambiguity regarding inclusion criteria. Patients excluded when ‘significant renal disease’ was present. No concise kidney outcomes documented; 1 patient developed transient kidney failure
Ready 1994	No concise kidney outcome measures reported
Southworth 2009	No concise kidney outcome measures reported
Varrassi 1999	No concise kidney outcomes measures reported; comment made that there was not statistically significant difference between treatment groups

CKD ‐ chronic kidney disease; CrCl ‐ creatinine clearance; eGFR ‐ estimated glomerular filtration rate; SCr ‐ serum creatinine